Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Кубанский научный медицинский вестник, 2019 Aim. This paper is aimed at identifying risk factors (RFs) and assessing their correlation in men and women with essential hypertension (stage III) under medical treatment. Materials and methods. Ninety-eight patients (45 men and 53 women) with essential
Lyubov N. Korichkina +2 more
doaj +1 more source
Solving Colorado's Health Professionals Shortage: Initial Lessons Learned From the Health Professions Initiative Evaluation [PDF]
, 2007 Gives an overview of the trust's 2005-08 Health Professions Initiative to address expected shortages in all healthcare professions, its impact so far, and the strategies grantees are implementing to help strengthen the training ...
Kaia Gallagher, Tanya Beer
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Awareness of Obesity and Diabetes in Libya: Insights From a Cross‐Sectional Study
Health Science ReportsBackground The escalating prevalence of obesity and diabetes mellitus (DM) worldwide poses significant challenges to global health systems, particularly in countries such as Libya, where public health infrastructure faces various constraints.
Zinelabedin Mohamed +6 more
doaj +1 more source
Health as a driving economic force [PDF]
This chapter illustrates the contribution which could be made to realising the Lisbon Strategy of the European Union for growth and jobs by innovative healthcare policy favouring a preventive orientation of healthcare.
Henke, Klaus-Dirk, Martin, Karl
core
Inequalities in the dental health needs and access to dental services among looked after children in Scotland: a population data linkage study [PDF]
, 2017 Background: There is limited evidence on the health needs and service access among children and young people who are looked after by the state. The aim of this study was to compare dental treatment needs and access to dental services (as an exemplar of ...
Clark , David +10 more
core +3 more sources
Exploring Delivery of Adolescent Preventive Health Services During the COVID-19 Pandemic: Perceptions and Experiences Shared by Healthcare Professionals [PDF]
, 2023 Brianna M White +3 more
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Current Situation of the Use of Neutrosophy to Improve Medical Decision Making and Preventive Healthcare in Ecuador [PDF]
Neutrosophic Sets and SystemsThis study systematically examines the applications of neutrosophic logic in Ecuadorian medicine, focusing on its role in improving medical decision making and preventive healthcare.
Franklin Parrales-Bravo +7 more
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