Results 161 to 170 of about 1,687,971 (294)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Research on optimization of C4 repair operation of Harmony electric locomotive based on preventive maintenance. [PDF]

PLoS One
Liu Y, Wu J, Wu Q.
europepmc   +1 more source

Development of a monitoring scheme for preventive maintenance of the cement machinery. [PDF]

Springerplus, 2016
Alhajjaji M, Boubeker B, Eljoumani S, Zamma A, Idiri M, Atik H.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Comprehensibility and impact of vehicle dashboard indicator light symbols on drivers' preventive maintenance compliance. [PDF]

PLoS One
Atombo C, Akple MS, Dumenya A, Adzimahe P.   +3 more
europepmc   +1 more source

Optimizing preventive maintenance policy: A data-driven application for a light rail braking system. [PDF]

Proc Inst Mech Eng O J Risk Reliab, 2017
Corman F, Kraijema S, Godjevac M, Lodewijks G.   +3 more
europepmc   +1 more source

The Management of the Industrial Maintenance at the International Level (I) [PDF]

When defining a maintenance policy, it must be held in mind the fact that there isn’t such a thing like “good maintenance policy” in itself; instead, for each industrial equipment should be adapted a particular maintenance method, coming to a technical ...
Florea PARVU, Gheorghe CARSTEA, Vasile DEAC, Florica BADEA, Constantin BAGU   +4 more
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preventive maintenance in urban public transport: the role of engine oil analysis. [PDF]

Sci Rep
Gołębiowski W, Wolak A, Zając G.
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source