Results 191 to 200 of about 652,972 (248)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system
FEBS Open Bio, EarlyView.An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
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Waste Management, 2013
The Waste Framework Directive (WFD-2008/98/EC) has set clear waste prevention procedures, including reporting, reviewing, monitoring and evaluating. Based on the WFD, the European Commission and will offer support to Member States on how to develop waste prevention programmes through guidelines and information sharing on best practices.
Antonis A, Zorpas, Katia, Lasaridi
openaire +2 more sources
The Waste Framework Directive (WFD-2008/98/EC) has set clear waste prevention procedures, including reporting, reviewing, monitoring and evaluating. Based on the WFD, the European Commission and will offer support to Member States on how to develop waste prevention programmes through guidelines and information sharing on best practices.
Antonis A, Zorpas, Katia, Lasaridi
openaire +2 more sources
Measuring the Effectiveness of Prevention
The Milbank Memorial Fund quarterly. Health and society, 1977The old adage, "An ounce of prevention is worth a pound of cure," is not a reasonable guide to the allocation of resources in the health care field. If it were, and we had preventive measures for all diseases, then health care would consist only of prevention: acute health care would only be a dim memory.
J R, Lave, L B, Lave
openaire +2 more sources
Preventing toxic exposures requires integrated approaches spanning communication, engineering, education, and policy domains to address diverse hazards across populations. Risk communication strategies employ principles of clarity, transparency, and cultural sensitivity to effectively convey toxicological information through multiple channels while ...
Eduardo Corona-Rodarte +3 more
+5 more sources
Eduardo Corona-Rodarte +3 more
+5 more sources
1992
Abstract Disinfection and sterilization are necessary to prevent cross-infection from equipment, surfaces and skin and are used in all hospitals: Decontamination renders an article safe for handling. Disinfection is used to reduce the number of micro-organisms on an object or surface, although the disinfectants used rarely destroy all
openaire +1 more source
Abstract Disinfection and sterilization are necessary to prevent cross-infection from equipment, surfaces and skin and are used in all hospitals: Decontamination renders an article safe for handling. Disinfection is used to reduce the number of micro-organisms on an object or surface, although the disinfectants used rarely destroy all
openaire +1 more source