Results 201 to 210 of about 1,228,014 (309)

Optimizing Multispecialty Preventive Care: Referral Patterns, Adherence, and Remission in Inflammatory Bowel Disease. [PDF]

Cureus
Bokaee SA, Deogaonkar A, Madani MS, Borum ML.   +3 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Factors related to participation in colorectal cancer screening in a Southern European region: a prevalence survey. [PDF]

Eur J Public Health
Martín-García P, Pichiule-Castañeda M, Domínguez-Berjón MF, Gandarillas-Grande A.   +3 more
europepmc   +1 more source

[Preventive work].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1994
openaire   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Experiences of heat stress and adapting practices among farmworkers in northwest Nicaragua: a qualitative study. [PDF]

BMJ Open
Pineda Reyes AL, Jaime A, Aragón A, López-Bonilla I, Pearce N, Caplin B, González-Quiroz M.   +6 more
europepmc   +1 more source

Harmonizing work with diseases treatment and prevention

Industrial Health, 2019
MUTO, Go, YOKOYAMA, Kazuhito, ENDO, Motoki, FUJINO, Yoshihisa   +3 more
openaire   +3 more sources

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Analysis of knowledge, acceptance and willingness to manage tuberculosis preventive treatment among Chinese village doctors. [PDF]

J Clin Tuberc Other Mycobact Dis
Wang Y, Hou Y, Yang Y, Zhang S, Li W, Wang D, Zhang B, Liu Z, Duan W, Du Y.   +9 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source