Results 101 to 110 of about 96,431 (347)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
REFINING PREDATOR-PREY PREFERENCE AT THE PREY DEMOGRAPHIC LEVEL FOR CHEETAH AND LION
, 2022 Traditional prey preference models estimate prey preference using a coarse species-specific body mass of three-quarters of the mean adult female body mass. This is widely assumed to estimate the average mass across prey populations, accounting for neonates, juveniles, sub-adults, and adults. However, this approach negates the models’ ability to predict
openaire +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
PLoS ONE, 2019 Recent studies revealed that reef corals can eat large-sized pelagic and benthic animals in addition to small planktonic prey. As follow-up, we document natural ingestion of sea slugs by corals and investigate the role of sacoglossan sea slugs as ...
Rahul Mehrotra +6 more
doaj +1 more source
Using a spatial overlap approach to estimate the risk of collisions between deep diving seabirds and tidal stream turbines : a review of potential methods and approaches [PDF]
, 2013 Peer reviewedPublisher ...
Scott, B E, Waggitt, J J
core +2 more sources
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
International Aquatic Research, 2017 A considerable body of the literature considers the potential impact of exotic predators on native prey organisms, while comparatively, few studies have asked whether and how native predators include novel prey types into their diet spectrum.
Xu Ouyang +5 more
doaj +1 more source
Time-Scale Analysis of Prey Preferences and Ontogenetic Shift in the Diet of European Hake Merluccius merluccius (Linnaeus, 1758) in Southern and Central Tyrrhenian Sea [PDF]
, 2022 Claudio D’Iglio +7 more
openalex +1 more source