Results 81 to 90 of about 14,708 (267)

Safety, Pharmacokinetics, and Pharmacodynamics of Osivelotor for Sickle Cell Disease: First‐in‐Human Studies in Healthy Participants and Patients

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 120-130, January 2026.
The investigational agent osivelotor, a small molecule hemoglobin (Hb) modifier in development for the treatment of sickle cell disease (SCD), acts by increasing Hb‐oxygen affinity and inhibiting the polymerization of sickle Hb. We report safety, pharmacokinetic (PK), and pharmacodynamic (PD) data from the first two phase 1 clinical trials of ...
Eleanor A. Lisbon, R. Clark Brown, Andrew Redfern, Ken Duchin, Aline Barth, Erika S. Roberts, Polo Gaputan, Kobina Dufu, Arthur Lo, Mira Patel Pochron, David R. Archer, Wai Chin, Karena Kong, Carla B. Washington, Adeyemi Adenola, Eric I. Zimmerman   +15 more
wiley   +1 more source

Prevalence of priapism in individuals with sickle cell disease and implications on male sexual function

Einstein (São Paulo), 2020
Objective To evaluate epidemiological aspects of priapism in patients with sickle cell disease, and these aspects impact on adult sexual function.
Mateus Andrade Alvaia, Heros Aureliano Antunes da Silva Maia, Alana de Medeiros Nelli, Carina Oliveira Silva Guimarães, Evanilda Souza de Santana Carvalho, José Murillo Bastos Netto, Eduardo de Paula Miranda, Cristiano Mendes Gomes, José de Bessa Júnior   +8 more
doaj   +2 more sources

A Peculiar Case of Priapism: The Hypercoagulable State in Patients with Severe COVID-19 Infection

European Journal of Case Reports in Internal Medicine, 2020
It is increasingly recognised that patients with severe COVID-19 infection have a significant risk of thromboembolic events. We describe a patient who rapidly deteriorated due to severe infection with COVID-19, and developed priapism in the last days of ...
G. Lam, Rowan McCarthy, R. Haider
semanticscholar   +1 more source

Association of Food Insecurity With Disease‐Related Complications and Healthcare Utilization for Patients With Sickle Cell Disease

Pediatric Blood &Cancer, Volume 73, Issue 1, January 2026.
ABSTRACT Background Food insecurity is one of several household material hardships (HMH) recognized for their impact on disease severity and healthcare utilization in patients with chronic disease. Sickle cell disease (SCD) is a chronic disease, disproportionately affecting patients of lower socioeconomic status, that results in high rates of disease ...
Sharjeel Syed, Andrew Palmer, Austin Wesevich, Kristen Wroblewski, Gabrielle Lapping‐Carr, Radhika Peddinti, Wendy S. Darlington   +6 more
wiley   +1 more source

Superselective embolization for high-flow priapism refractory to medical and surgical treatments

BMC Urology, 2020
Background This study aimed to report long-term outcome of superselective embolization in patients with high-flow priapism refractory to medical and surgical treatments.
Y. Bi, M. Yi, Zepeng Yu, Xinwei Han, Jianzhuang Ren   +4 more
semanticscholar   +1 more source

Genotype Differences and Hydroxyurea Utilization Among Adults With Moderate to Severe Sickle Cell Disease

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 1, January 2026.
ABSTRACT Backgrounds Hydroxyurea (HU) remains underutilized in adults with sickle cell disease (SCD) despite proven benefits. Current HU guidelines primarily target sickle cell anemia (SCA), overlooking other genotypes. Objectives This study examined HU utilization patterns across genotypes among adults considered to have moderate to severe SCD ...
Siang‐Hao Cheng, Enrico M. Novelli, Hyeun Ah Kang, Terri V. Newman, Kangho Suh   +4 more
wiley   +1 more source

Successful treatment with olanzapine and aripiprazole of a schizophrenic patient who developed priapism after switching from risperidone to paliperidone

Neuropsychopharmacology Reports
Background Ischemic priapism is a rare pathological condition, and delayed intervention can result in irreversible sequelae. Most cases are attributed to the use of antipsychotics.
Saki Kawahara, Kazuyuki Watanabe, Kazuhiko Inazumi, Makoto Kimura, Yuki Hirose, Hiraki Koishikawa   +5 more
doaj   +1 more source

Priapism

Silberman M, Leslie SW, Hu EW.
europepmc   +2 more sources

Two cases of priapism associated with Quetiapine

Psychiatry and Clinical Psychopharmacology, 2018
Priapism is a painful, prolonged erection that occurs without any sexual stimulation. It is an emergency that may lead impotence, urinary retention, and gangrene as long-term devastating consequences.
Özge Şahmelikoğlu Onur, Hatice Kızılkale, Hüseyin Yumrukçal, Meltem Gürü   +3 more
doaj   +1 more source

Priapism in a Patient with Rectal Adenocarcinoma [PDF]

, 2023
Navdeep Dehar, Justin Tong, Zain Siddiqui, Michael Leveridge, Anna Tomiak   +4 more
openalex   +1 more source