Results 101 to 110 of about 947,110 (306)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Measuring welfare changes from commodity price stabilization in small open economies [PDF]
The authors extend the widely used Newbery and Stiglitz (1981) approach to measuring welfare changes from commodity price stabilization to a general equilibrium setting.
Coleman, Jonathan R., Jones, Chris
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Market Forces and Price Ceilings: A Classroom Experiment [PDF]
The effect of price controls on competitive equilibrium is a standard topic in many undergraduate economics courses. This classroom experiment demonstrates the effect of rent control (price ceilings) on the market for apartments.
Jamie Brown Kruse +2 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A model of parallel imports of pharmaceuticals with endogenous price controls [PDF]
A model is developed to explore the behavior of an original manufacturer with a patent in response to a policy that permits parallel import competition from a country with price controls on the patented good.
Katherine Sauer
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Analysis of Emerging Markets and Resilience: A Study of Zambian Food Market
Journal of Arts, Humanities and Social ScienceThis study investigates how labor and input costs affect pricing, profits, and resilience in Zambia's food retail stores. Escalating production costs—worsened by currency depreciation and a reliance on imports—have led to significant price hikes ...
Gift Simucho, Marvin Kabubi
doaj +1 more source
Modelling complex livestock-agricultural systems at a regional scale : A case study in La Reunion [PDF]
, 2008 Réunion Island, situated in the Indian Ocean, presents a unique case study to model regional bio-economic parameters of the dairy industry. It is a good example of a closed system for movement of animals, available labour, consumption of products, and ...
Alary, Véronique +4 more
core +1 more source