Results 191 to 200 of about 2,488,526 (252)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

A comparative approach for selecting orthologous candidate genes in genome-wide association studies across multiple species. [PDF]

Plant Physiol
Whitt L, Mahood EH, Ziegler G, Luebbert C, Gillman JD, Norton GJ, Price AH, Salt DE, Dilkes BP, Baxter I.   +9 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum. [PDF]

Nat Commun
Perry TA, Deng Y, Hulley PA, Maciewicz RA, Mitchelmore J, Larsson S, Gogain J, Brachat S, Struglics A, Appleton CT, Kluzek S, Arden NK, Felson D, Bondi L, Kapoor M, Lohmander LS, Welting TJ, Walsh DA, Valdes AM, Jostins-Dean L, Watt FE, Tom BDM, Vincent TL, STEpUP OA Consortium.   +23 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Discovery of MK-2118, a Small-Molecule Agonist of STING. [PDF]

ACS Med Chem Lett
Henderson T, Altman MD, Buevich AV, Cash B, Cemerski S, Chang W, Chen Y, Childers M, Cumming J, Dandliker PJ, Feng G, Haidle A, Hayes RP, Ho T, Jewell JP, Kariv I, Knemeyer I, Kopinja J, Lacey BM, Laskey J, Lesburg CA, Liang R, Lim J, Long BJ, Lu M, Ma Y, Minnihan EC, Otte RD, O'Donnell G, Pan BS, Perera SA, Piesvaux JA, Presland JP, Price L, Rakhilina L, Sauvagnat B, Schroeder GK, Sharma S, Trotter BW, Tyagarajan S, Woo H, Wyss DF, Xu S, Addona GH, Bennett DJ.   +44 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

A cost-based-plus pricing approach for repurposed tiratricol in the treatment of Allan-Herndon-Dudley syndrome. [PDF]

Orphanet J Rare Dis
Manders E, Keestra S, Bannenberg W, van der Wel V, de Visser S, Hollak C.   +5 more
europepmc   +1 more source