Results 111 to 120 of about 159,127 (295)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Historical Writing in Britain 1688-1830: Visions of History
, 2014 Historical Writing in Britain, 1688-1830 is concerned with developments in historical discourse during the long eighteenth century. The collection investigates a number of interrelated themes: the contested and unstable nature of generic boundaries ...
Dew, Ben, Price, Fiona L., Price, Fiona
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Oral History Interview with Lore Price, December 3, 1989
, 1989 Interview with Lore Price, a Holocaust survivor from Gelsenkirchen, North Rhine-Wesphalia, Germany. Price discusses her family, growing up, antisemitism, the Kristallnacht and subsequent growth of arrests and deportations, the Berlin ghetto, the Riga ...
Price, Lore, Rosen, Keith G.
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Do hedonic price indexes change history? The case of electrification [PDF]
Rapid price decreases for ICT-products in the 1990s have been largely attributed to the introduction of hedonic price indexes. Would hedonic price indexing also have large effects on measured price and productivity during earlier technological ...
Edquist, Harald
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Oral History Program Interview: Dorothy Louise Price Rose
, 1981 CALIFORNIA STATE COLLEGE, BAKERSFIELD\ud CALIFORNIA ODYSSEY\ud The 1930s Migration to the Southern San Joaquin Valley\ud Oral History Program\ud Interview Between\ud INTERVIEWEE: Dorothy Louise Price Rose\ud PLACE OF BIRTH: Lamar, Johnson County ...
Rose, Dorothy Louise Price
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source