Results 241 to 250 of about 1,974,113 (319)

The UK Antimicrobial Registry (UKAR): an overview of the first 20 months of recruitment. [PDF]

JAC Antimicrob Resist
Sneddon J, Parr R, Woods J, MacDonald RIR, Sandoe JAT, Baltas I, Seaton RA, El Sakka N, Kaye C, Macfarlane GJ, Jones GT, UKAR Study Principal Investigators .   +11 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Food prices and food crises since 2020: evidence from Mali, northeast Nigeria, Sudan, and northern Uganda. [PDF]

Disasters
Wiggins S, Ahmed BY, Akullo B, Barry B, Dudu J, Eronmhonsele J, Kiwala Y, Ogisi D, Onokerhoraye A, Opio J, Patel N, Sulieman H.   +11 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Foundations of Ecological and Evolutionary Change. [PDF]

Ecol Evol
Duthie AB, Luque VJ.
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

A Bayesian network for identifying causes of breathlessness using a national electronic medical records (EMR) database. [PDF]

Sci Rep
Kabir A, Devaux A, Jenkins C, Martin A, Sunjaya A, Gianacas C, Price D, Eleangovan N, Campain A.   +8 more
europepmc   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Mental Health Impact of Massage and Massage Therapy for Survivors of Domestic and Family Violence and/or Sexual Abuse: A Scoping Review. [PDF]

Int J Ther Massage Bodywork
DiPronio S, Fogarty S.
europepmc   +1 more source