Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Stock Forecasting Based on Informational Complexity Representation: A Framework of Wavelet Entropy, Multiscale Entropy, and Dual-Branch Network. [PDF]
Entropy (Basel)Tian G, Xu C, Yang Y.
europepmc +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Nickel price forecasting based onempirical mode decomposition and deep learning model with expansion mechanism. [PDF]
PLoS OneLi J, Yu Z, Zhang J, Meng W.
europepmc +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Finite-Length Spatiotemporal Modelling for Housing Price Network Spillovers. [PDF]
Entropy (Basel)Qiu L, Jiao Y, Dong G, Cui G.
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Light-activated thiomaleimide crosslinking stabilizes collagen mimetic peptide triple helix.
Chem Commun (Camb)Castro RA +3 more
europepmc +1 more source
Operational intelligence for immunization recovery: mapping system shocks and capacity to zero-dose debt and outbreak risk. [PDF]
Front Health ServRamakrishnan S, Vignesh U, Parvathi R.
europepmc +1 more source