Results 61 to 70 of about 89,264 (281)

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

open access: yesAdvanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel   +19 more
wiley   +1 more source

“West Germans Don’t Even Know about it”: An Analysis of Narrations by East German COMECON Pipeline Workers after the Fall of the Wall

open access: yesAustralian and New Zealand Journal of European Studies, 2010
The paper is concerned with communicative practices of former GDR contract workers who were involved in the construction of a trans-national pipeline in the former Soviet Union, in the 1970s and 1980s. This paper draws on the ethnography of communication
Jeannette Prochnow
doaj   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

open access: yesAdvanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li   +7 more
wiley   +1 more source

Quantifying Additive Manufacturing Vapor Plumes Using Laser‐Induced Breakdown Spectroscopy, Synchrotron X‐Ray Radiography and Simulations

open access: yesAdvanced Science, EarlyView.
This study presents a novel in situ laser‐induced breakdown spectroscopy system for monitoring metal vapors produced by the intense laser‐metal interactions in laser powder bed fusion additive manufacturing and laser welding. The insights from this new technique reveal changes in alloy compositions and provide the first in situ validation of multi ...
Anna C. M. Getley   +8 more
wiley   +1 more source

Is Shame Managed Through Mind-Wandering?

open access: yesEurope's Journal of Psychology, 2019
Shame is a notoriously unpleasant emotion, and although claims about the mechanisms through which we might manage it are none too scarce, relatively little empirical evidence is available concerning how people tend to cope with it.
Neda Sedighimornani
doaj   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

open access: yesAdvanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel   +11 more
wiley   +1 more source

Pride

open access: yesRadical History Review
Jessica L. Tracy   +2 more
  +10 more sources

Pride, Shame and Group Identification

open access: yesFrontiers in Psychology, 2016
Self-conscious emotions such as shame and pride are emotions that typically focus on the self of the person who feels them. In other words, the intentional object of these emotions is assumed to be the subject that experiences them. Many reasons speak in
Alessandro eSalice   +1 more
doaj   +1 more source

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