Results 61 to 70 of about 9,815,408 (294)

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

open access: yesAdvanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García   +13 more
wiley   +1 more source

Studying National Identity and Personal Historical Experience in the Titular Armenian Ethnic Group and in the Armenian Diaspora in Russia

open access: yesРоссийский психологический журнал, 2018
Introduction. Studying the psychological phenomenon of national identity from the subjective perspective merits special attention. This paper: (a) introduces a new concept of personal historical experience and (b) provides justification for this concept ...
Asya S. Berberyan, Oksana R. Tuchina
doaj   +1 more source

The impacts of management interventions on the sociality of African lions (Panthera leo): Implications for lion conservation

open access: yesEcological Solutions and Evidence, 2022
African lion (Panthera leo) populations normally consist of several neighbouring prides and multiple adult males or groups of males that interact competitively. In large, open systems, cub defence from infanticidal males and territory defence drive group
Orla K. McEvoy   +2 more
doaj   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

open access: yesAdvanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes   +14 more
wiley   +1 more source

Davis County Utah Pride 2023 Connell O\u27Donovan Speaking [1]

open access: yes, 2023
Color photograph of Connell O\u27Donovan Speaking at the 2023 Davis County Pride ...
Ann Clark
core  

Charting Endocrine Progenitors Across Species and Organs

open access: yesAdvanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing   +21 more
wiley   +1 more source

Neutronics analysis of TRIGA Mark II research reactor

open access: yesNuclear Engineering and Technology, 2018
This article presents clean core criticality calculations and control rod worth calculations for TRIGA (Training, Research, Isotope production-General Atomics) Mark II research reactor benchmark cores using Winfrith Improved Multi-group Scheme-D/4 (WIMS ...
Haseebur Rehman, Siraj-ul-Islam Ahmad
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

open access: yesAdvanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj   +25 more
wiley   +1 more source

A Global Methane Observation System to Reduce Uncertainty for Anthropogenic and Natural Sources and Sinks for Detecting and Attributing Climate Feedbacks

open access: yesAdvanced Science, EarlyView.
Conceptual illustration of a Global Ecosystem Methane Observing System (GEM‐OS) integrating satellites, aircraft, atmospheric networks, and ecosystem measurements to quantify methane emissions from anthropogenic and natural sources. The multi‐scale observing framework improves source attribution, reduces uncertainty in regional methane budgets, and ...
P. Ciais   +32 more
wiley   +1 more source

1996 Utah Pride Guide Book

open access: yes, 1969
Text document The 1996 Utah Pride Guide Vol. 1 Issue 1. general statement by Co-Chairs of the pride parade Carrie Gayler and Jeff Freedman, Pride Timeline, List of entertainers and other eventsConverted from .jpg to .pdf for compatibility; pages ...
Carrie Gayler and Jeff Freedman (Pride Co-Chairs) Photo: Kim Russo, Bruce Harmon,John Wilkes
core  

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