PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balance
Blood, 2014 Key PointsMyeloma cells are highly sensitive to PRIMA-1Met, independent of p53. PRIMA-1Met induces myeloma cell death by impairing GSH/ROS balance.
Tessoulin, Benoît +10 more
openaire +4 more sources
Effects of the Mutant TP53 Reactivator APR-246 on Therapeutic Sensitivity of Pancreatic Cancer Cells in the Presence and Absence of WT-TP53 [PDF]
, 2022 The TP53 tumor suppressor is mutated in ~75% of pancreatic cancers. The mutant TP53 protein in pancreatic ductal adenocarcinomas (PDAC) promotes tumor growth and metastasis.
Abrams S. L. +13 more
core +1 more source
Recent discoveries in the cycling, growing and aging of the p53 field [PDF]
, 2012 The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed.
Demidenko, Zoya N., McCubrey, James A.
core +2 more sources
PRIMA-1met Induces Autophagy in Colorectal Cancer Cells With Different p53 Status
, 2020 Abstract Background: PRIMA-1met (APR246), a methylated form of PRIMA-1 (p53-reactivation and induction of massive apoptosis-1, APR-017), targets mutant p53 for restoring its wild-type structure and function. We previously demonstrated that PRIMA-1met was efficient in suppressing the growth of colorectal cancer (CRC) cells in a p53-independent ...
Xiao-lan Li +4 more
openaire +1 more source
Mutant p53–Nrf2 axis regulates the proteasome machinery in cancer
Molecular & Cellular Oncology, 2017 The proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors.
Kamil Lisek +2 more
doaj +1 more source
A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C [PDF]
, 2019 Aim: The p53 cancer mutation Y220C creates a conformationally unstable protein with a unique elongated surface crevice that can be targeted by molecular chaperones.
Bauer, Matthias +9 more
core +1 more source
ChemBioChem, Volume 21, Issue 24, Page 3525-3538, December 11, 2020., 2020 Doing things differently: We have metabolically engineered an E. coli strain by reconfiguring the methionine biosynthetic pathway to create a bacterial system with a trans‐sulfuration pathway for in‐cell production and incorporation of l‐azidohomoalanine.
Christian Johannes Schipp +7 more
wiley +1 more source
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes [PDF]
, 2012 It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the cell.
Abate-Shen +229 more
core +2 more sources
Modulation of p53's transcriptional function by small molecules [PDF]
, 2011 p53 tumour suppressor is a transcriptional factor which induces apoptosis or growth arrest in response to stress thus eliminating damaged cells. p53 function is frequently abrogated in tumours either via inactivation mutations in the TP53 gene or by ...
Nikulenkov, Fedor
core +1 more source
Molecular & Cellular Oncology, 2017 Effective therapeutic strategies to target mutant tumor protein p53 (TP53, best known as p53) cancers remain an unmet medical need. We found that mutant p53 impairs the function of nuclear factor (erythroid-derived 2)-like 2 (NFE2L2, commonly known as ...
Nicholas J. Clemons +3 more
doaj +1 more source