Results 61 to 70 of about 955 (158)

Pathway‐level mutational signatures predict breast cancer outcomes and reveal therapeutic targets

British Journal of Pharmacology, Volume 182, Issue 23, Page 5734-5747, December 2025.
Abstract Background and Purpose In order to significantly improve the therapeutic treatment of breast cancer, the exploration of underlying genetic and molecular differences is absolutely necessary. Here, our goal was to integrate mutational status of entire pathways to reveal molecular pathway interactions determining survival. Experimental Approach A
Máté Posta, Balázs Győrffy
wiley   +1 more source

APR-246/PRIMA-1MET reverse squamous metaplasia in human conjunctival epithelium [PDF]

, 2015
目的探讨APR-246/PRIMA-1MET对人结膜鳞状上皮化生（squamousmetaplasia，SM）的影响及研究其相关作用机制。 方法结膜组织以不同浓度的APR-246/PRIMA-1MET（0μM，3μM，15μM）空气暴露培养不同时间（4，8，12天）。HE染色检测结膜上皮的形态改变；免疫组织化学染色检测结膜上皮特异性功能相关基因的表达；实体显微镜观察测算结膜周边新生上皮细胞的数量和速度；免疫荧光染色和实时荧光PCR检测上皮增殖及分化状态和Wnt信号通路相关基因的表达 ...
李晶
core  

Abnormal accumulation of p53 predicts radioresistance leading to poor survival in patients with endometrial carcinoma [PDF]

, 2019
journal ...
0000001825, 0000001850, 0000001922, 0000003936, 0000003944, 0000004467, AKIYAMA, Azusa, Hosokawa, Yoshihiko, MINAGUCHI, Takeo, Nishida, Keiko, OCHI, Hiroyuki, Sakurai, Manabu, SATOH, Toyomi, SHIKAMA, Ayumi, TASAKA, Nobutaka   +14 more
core   +1 more source

Long‐Term Effects of High‐Intensity Aerobic Training on Metabolic Syndrome: An 8‐Year Follow‐Up Randomized Clinical Trial

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 2, April 2025.
ABSTRACT Background Metabolic syndrome (MetS) is a set of five cardiometabolic risk factors that typically worsen with age. One exercise‐training programme is effective at improving those factors in middle‐aged individuals with MetS. To our knowledge, exercise‐training efficacy as MetS individuals age has not been explored.
Felix Morales‐Palomo, Alfonso Moreno‐Cabañas, Laura Alvarez‐Jimenez, Diego Mora‐Gonzalez, Ricardo Mora‐Rodriguez   +4 more
wiley   +1 more source

A Novel Synonymous Variant in SQSTM1 Causes Neurodegeneration With Ataxia, Dystonia, and Gaze Palsy Revealed by Urine‐Derived Cells‐Based Functional Analysis

Molecular Genetics &Genomic Medicine, Volume 12, Issue 11, November 2024.
In Japanese siblings with multisystem neurodegeneration, including cerebellar ataxia, dystonia, and vertical gaze palsy, we identified compound heterozygous variants in SQSTM1(NM_003900.5): c.1A>G p.(Met1?) in the initial codon, and c.969G>A. An SQSTM1 protein expression assay using urine‐derived cells (UDCs), which were obtained using noninvasive ...
Shinji Masuko, Mitsuto Sato, Katsuya Nakamura, Kohei Hamanaka, Satoko Miyatake, Yuji Inaba, Tomoki Kosho, Naomichi Matsumoto, Yoshiki Sekijima   +8 more
wiley   +1 more source

Double Chalcogen Bonding Recognition Arrays in Solution

Chemistry – A European Journal, Volume 30, Issue 60, October 28, 2024.
This work focused on the dimerization of newly synthetized Pyrselen derivatives, being evaluated both at the solid state (by XRD analysis) and in solution, by 77Se NMR dilution experiments carried out in CDCl3 at 298 K. Notably, the self‐assembly at the liquid state is persistently observed in different solvents, highlighting the charge‐transfer ...
Deborah Romito, Hanspeter Kählig, Paolo Tecilla, Gabriele C. Sosso, Davide Bonifazi   +4 more
wiley   +1 more source

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance [PDF]

, 2012
The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK).
Abell, Abken, Abken, Acquas, Ahn, Alessi DR, Amaravadi, Ambrosetti, Amler, Andre, Andreeff, Antoch, Arteaga, Atasoy, Auberger, Auberger, Auernhammer, Awada, Ayral-Kaloustian, Bakkenist, Ball, Bartek, Baselga, Basilico, Batist, Belvin, Belvin, Belvin, Bendell, Bendtzen, Benjamin, Berberich, Bernhardt, Bierer, Birnbaum, Bissell, Blagosklonny, Blagosklonny, Blagosklonny, Blagosklonny, Bonati, Bouscary, Bouscary, Bouscary, Brown, Brown, Calvo, Campbell, Caro, Cervello, Cervello, Cervello, Chang, Chapman, Chen, Chen, Cheng, Cheng, Choi, Citrin, Cloos, Cocco, Coin, Conejo-Garcia, Cook, Cook, Croasdell, Cross, D'Ambrosio, D'Orazi, Damia, Dammacco, Dang, Darnell, Darzynkiewicz, Davey, Davis, De Pover, Del Sal, Demetri, Dennis, Di Cristofano, Ding, Direnzo, Dong, Duronio, Eckhardt, Engelman, Engelman, Escudier, Evers, Falchook, Felip, Festuccia, Feun, Figlin, Finkel, Flachook, Flaherty, Flaherty, Fotedar, Foà, Friedman, Furman, Furman, Gadgeel, Gaither, Galle, Garcia-Echeverria, Garraway, Geissler, Gibbons, Giese, Gilmer, Glazer, Glynn, Gordon, Goutopoulos, Grant, Gray, Grever, Guan, Guan, Guichard, Ha, Haas-Kogan, Hall, Hallahan, Hammond, Hedley, Hedley, Heinemann, Heitman, Helin, Herlyn, Herlyn, Hollander, Hong, Horwitz, Houghton, Howell, Huang, Iozzo, James, Jang, Jendrossek, Jiang, Johnsen, Jongstra, Kaelin, Kaina, Kane, Kaufmann, Kaufmann, Kaufmann, Kelley, Khanna, Khwaja, Kimmelman, Knudsen, Koh, Konopleva, Kopelovich, Korn, Koromilas, Kotani, Kovalchuk, Kraft, Kraft, Kraft, Kramer, Kroemer, Kroemer, Kroemer, Lain, Landberg, Lannutti, Lawrence, Leber, Lee, Lin, Lippincott-Schwartz, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Liu, Lo, Lo, Lo, Longo, Lopez, Lu, Lu, Luedde, Macewan, Maestro, Maffucci, Maguire, Major, Marais, Marais, Marais, Marimuthu, Marks, Martelli, Martelli, Martelli, Martelli, Martelli, Martelli, Martelli, Martelli, Martelli, Mayer, Mayeux, McCann, McCubrey, McCubrey, McCubrey, McCubrey, McCubrey, McCubrey, McDaid, McDonald, Menendez, Menendez, Menendez, Merchant, Mercuri, Mijatovic, Milella, Mohammad, Montalto, Montalto, Munshi, Murata, Musgrove, Myers, Naing, Nakashima, Namchuk, Nathanson, Nawrocki, Nawrocki, Nicoletti, Nicoletti, Nijman, Nilsson, Nilsson, Noda, Noguchi, O'Dwyer, O'Dwyer, Oktay, Ouellet, Pachter, Padera, Padera, Panayotou, Pandolfi, Pandolfi, Pani, Park, Patel, Platanias, Platanias, Poli, Polman, Poroshina, Powis, Prives, Quart, Ramalingam, Reck, Ribas, Ribas, Ricart, Rieber, Roberts, Robertson, Rommel, Rosen, Rosen, Rosen, Rosen, Rosen, Roy, Roy, Ruggero, Rupprecht, Salmeron, Samuels, Sanchez, Sanders, Santoro, Sarkar, Sarkaria, Scaglioni, Schadendorf, Schellens, Schmidmaier, Schmidmaier, Schmidt, Schmidt, Schoffski, Schwartz, Scott, Sebolt-Leopold, Sebti, Selivanova, Sellers, Sellers, Sellers, Settleman, Sharan, Shaw, Shaw, Shellooe, Shields, Simeone, Simon, Sitzmann, Siu, Slingluff, Smalley, Smalley, Smalley, Smalley, Smalley, Smalley, Smith, Solary, Solit, Soria, Sotgia, Spratlin, Springer, Stathopoulos, Stegmeier, Stern, Stoeltzing, Stromblad, Stromblad, Su, Suh, Sun, Sutherland, Syed, Syljuasen, Tafuri, Tang, Theurkauf, Thompson, Thompson, Tran, Tse, Turhan, Valerie, van den Bent, van Montfort, van Montfort, Varticovski, Vassilev, Vazquez-Martin, Vidal, Vogt, Wacheck, Wang, Wang, Wang, Warmuth, Waterfield, Weinberg, Weiss, Weiss, Weissgerber, Weissman, Wessels, Wicha, Williams, Williams, Williamson, Winquist, Workman, Wrana, Xing, Yahalom, Yonezawa, Yu, Yung, Zacksenhaus, Zhang, Zhang, Zhang, Zhang, Zheng, Zhou, Zhou, Zopf   +402 more
core   +2 more sources

Organoids: development and applications in disease models, drug discovery, precision medicine, and regenerative medicine

MedComm, Volume 5, Issue 10, October 2024.
Four main applications of organoids. The main applications of organoids include the construction of disease models, drug screening and toxicity evaluation, precision medicine, and regenerative medicine. Abstract Organoids are miniature, highly accurate representations of organs that capture the structure and unique functions of specific organs ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Guoqiang Cao, Lanjuan Li, Hongcui Cao   +6 more
wiley   +1 more source

Mutant p53 reactivators protect breast cancer cells from ferroptosis

Cell Biochemistry and Function, Volume 42, Issue 4, June 2024.
Abstract Ferroptosis is a novel nonapoptotic form of cell death characterized by iron‐dependent reactive oxygen species‐mediated lipid peroxidation. In several different cell systems, the tumor suppressor p53 can enhance sensitivity to ferroptotic inducers. At least half of all human cancers show loss of function of p53.
Dewmi Sandaru Rathnayake, Samkeliso Dlamini, Kadry Elkalawozgy, L. M. Viranga Tillekeratne, William R. Taylor   +4 more
wiley   +1 more source

Analysis of disulfidptosis‐ and cuproptosis‐related LncRNAs in modulating the immune microenvironment and chemosensitivity in colon adenocarcinoma

IET Systems Biology, Volume 18, Issue 2, Page 55-75, April 2024.
1. A Comprehensive Analysis of Disulfidptosis‐ and Cuproptosis‐Related Immune Microenvironment and Chemosensitivity in COAD. 2. A prognostic model of COAD related to Disulfidptosis‐ and Cuproptosis was established. Abstract The main objective was to establish a prognostic model utilising long non‐coding RNAs associated with disulfidptosis and ...
Qiang Fan, Guang‐Bo Wu, Min Chen, Lei Zheng, Hong‐Jie Li, Lv‐Zhu Xiang, Meng Luo   +6 more
wiley   +1 more source