Results 71 to 80 of about 955 (158)

Mutant p53 as a guardian of the cancer cell [PDF]

, 2019
Forty years of research have established that the p53 tumor suppressor provides a major barrier to neoplastic transformation and tumor progression by its unique ability to act as an extremely sensitive collector of stress inputs, and to coordinate a ...
A Ali, A Kieser, A Narendran, A Parrales, A Polotskaia, A Restle, AJ Wolpaw, AK Frank, BK Linderholm, C Kandoth, C Zhang, CA Larsson, CD Kamat, D Bergamaschi, D Li, D Li, D Li, D Malkin, D Senft, D Walerych, D Walerych, D Walerych, DP Liu, E Campaner, E Ingallina, E Martynova, E Morselli, E Sahai, EM Alexandrova, F Kruiswijk, F Mantovani, F Mantovani, F Rohrig, F Valenti, F Vogiatzi, Fiamma Mantovani, G Bossi, G Fontemaggi, G Minin Di, G Sorrentino, G Sorrentino, G Zhou, Giannino Del Sal, H Rahnamoun, H Song, H Zhang, HN Lee, J Luo, JE Girardini, JL Chee, K Lisek, K Liu, L Chen, L Weisz, Licio Collavin, M Adorno, M Cordani, M Fang, M McLaughlin, M Wang, MG Heiden Vander, ML Mendillo, MP Kim, MW Pickup, NN Pavlova, OA O’Connor, OC Rodriguez, P Liao, P Timpson, PG Richardson, PJ Mullen, PM Neilsen, PY Wang, PY Wang, R Gomez-Pastor, RA Frum, RM Connolly, S Agostino Di, S Basu, S Choudhury, S Kozono, S Madar, S Mizuarai, S Singh, S Wei, T Cooks, T Cooks, T Koga, T Terzian, TA Nguyen, TD Halazonetis, V Garcia, VJ Bykov, VJN Bykov, WA Freed-Pastor, WA Yeudall, X Peng, X Zhang, YA Suh   +98 more
core   +1 more source

Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy

Cancer Communications, Volume 44, Issue 3, Page 297-360, March 2024.
Abstract Cancer is a leading cause of death worldwide. Targeted therapies aimed at key oncogenic driver mutations in combination with chemotherapy and radiotherapy as well as immunotherapy have benefited cancer patients considerably. Tumor protein p53 (TP53), a crucial tumor suppressor gene encoding p53, regulates numerous downstream genes and cellular
Bin Song, Ping Yang, Shuyu Zhang
wiley   +1 more source

Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models [PDF]

, 2017
Over the past 20 years, huge advances have been made in modelling human diseases such as cancer using genetically modified mice. Accurate in vivo models are essential to examine the complex interaction between cancer cells, surrounding stromal cells ...
Marsh Durban, Victoria, Phesse, Toby, Sansom, Owen J.   +2 more
core   +2 more sources

324 Improvement of epidermal covering on AEC patients with severe skin erosions by PRIMA-1MET [PDF]

Journal of Investigative Dermatology, 2021
E. Aberdam, L.N. Roux, P. Secrétan, F. Boralevi, J. Schlatter, F. Morice-Picard, S. Sol, C. Bodemer, C. Missero, S. Cisternino, D. Aberdam, S. Hadj-Rabia   +11 more
openaire   +1 more source

p53-dependent and -independent mechanisms of p53-targeting small molecules [PDF]

, 2020
Tumor suppressor p53 (Tp53) is mutated in around half of human cancers, while in wild type p53 cells its activity is continuously inhibited by MDM2 through proteasome degradation resulting in the loss of its function.
Zhu, Jiawei
core   +1 more source

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL [PDF]

, 2018
T-cell prolymphocytic leukemia (T-PLL) is a rare and poor-prognostic mature T-cell malignancy. Here we integrated large-scale profiling data of alterations in gene expression, allelic copy number (CN), and nucleotide sequences in 111 well-characterized ...
Altmueller, J., Andersson, E. I., Beier, F., Braun, T., Brümmendorf, T. H., Crispatzu, G., Elenitoba-Johnson, K. S. J., Ferreira, M. S. Ventura, Frommolt, P., Haferlach, T., Hallek, M., Herling, C. D., Herling, M., Hopfinger, G., Lanasa, M., Maurer, B., Mayer, P., Moriggl, R., Mustjoki, S., Newrzela, S., Nürnberg, P., Oberbeck, S., Peifer, M., Pflug, N., Pützer, S., Reinhardt, H. C., Riabinska, A., Schrader, A., Stern, M. -H., Stilgenbauer, S., Vasyutina, E., von Jan, J., Warner, K., Weit, N., Yadav, B., Zha, S.   +35 more
core   +3 more sources

Additional file 2: of PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level

, 2019
Supplementary information for figures. (PPTX 6460 kb)
Mlakar, Vid, Mlakar, Simona Jurkovic, Lesne, Laurence, Marino, Denis, Komal Rathi, Maris, John, Ansari, Marc, Gumy-Pause, Fabienne   +7 more
openaire   +1 more source

PRIMA-1 induces autophagy in cancer cells carrying mutant or wild type p53. [PDF]

, 2013
PRIMA-1 is a chemical compound identified as a growth suppressor of tumor cells expressing mutant p53. We previously found that in the MDA-MB-231 cell line expressing high level of the mutant p53-R280K protein, PRIMA-1 induced p53 ubiquitination and ...
Foggetti G., Fronza G., MASIELLO, PELLEGRINO, MASINI, MATILDE, Menichini P., Ottaggio L., Russo D.   +6 more
core   +1 more source

PRIMA-1^MET Does Not Restore Vitamin D Sensitivity to MDA-MB-231 and MDA-MB-468 Triple-Negative Breast Cancer Cells. [PDF]

ACS Omega, 2023
Kotob SN, Kelts JL.
europepmc   +1 more source

PRIMA‑1^met induces autophagy in colorectal cancer cells through upregulation of the mTOR/AMPK‑ULK1‑Vps34 signaling cascade. [PDF]

Oncol Rep, 2021
Li XL, Zhou J, Xia CJ, Min H, Lu ZK, Chen ZR.   +5 more
europepmc   +1 more source