Results 81 to 90 of about 955 (158)

Chronic inflammation and cancer: potential chemoprevention through nuclear factor kappa B and p53 mutual antagonism [PDF]

, 2014
Activation of nuclear factor-kappa B (NF- κB) as a mechanism of host defense against infection and stress is the central mediator of inflammatory responses.
Ashish Bhattacharjee, Asif Ali, Mahadeb Pal, Narayan C Mandal, Srabani Pal, Subhash C Mandal   +5 more
core   +2 more sources

Correction: PRIMA-1MET induces mitochondrial apoptosis through activation of caspase-2 [PDF]

Oncogene, 2017
J Shen, H Vakifahmetoglu, H Stridh, B Zhivotovsky, K G Wiman   +4 more
openaire   +1 more source

APR-246/PRIMA-1^MetInhibits and Reverses Squamous Metaplasia in Human Conjunctival Epithelium

Investigative Opthalmology & Visual Science, 2016
Squamous metaplasia is a common pathologic condition in ocular surface diseases for which there is no therapeutic medication in clinic. In this study, we investigated the effect of a small molecule, APR-246/PRIMA-1(Met), on squamous metaplasia in human conjunctival epithelium.Human conjunctival explants were cultured for up to 12 days under airlifting ...
Jing, Li, Cheng, Li, Guoliang, Wang, Zhen, Liu, Pei, Chen, Qichen, Yang, Nuo, Dong, Huping, Wu, Zuguo, Liu, Wei, Li   +9 more
openaire   +2 more sources

Molecular and Cellular Function of p63 in Skin Development and Genetic Diseases [PDF]

: The transcription factor p63 is a master regulator of multiple ectodermal derivatives. During epidermal commitment, p63 interacts with several chromatin remodeling complexes to transactivate epidermal-specific genes and repress transcription of simple ...
Caterina Missero, Daniela Di Girolamo, Enzo Di Iorio   +2 more
core   +2 more sources

Strong synergy with APR-246 and DNA-damaging drugs in primary cancer cells from patients with TP53 mutant High-Grade Serous ovarian cancer [PDF]

, 2016
Daria Glaessgen, Jessica Alfredsson, Klas G. Wiman, Nina Mohell, Svetlana Bajalica-Lagercrantz, Åsa Fransson   +5 more
core   +3 more sources

Antitumor Effects of PRIMA-1 and PRIMA-1^Met (APR246) in Hematological Malignancies: Still a Mutant P53-Dependent Affair? [PDF]

Cells, 2021
Menichini P, Monti P, Speciale A, Cutrona G, Matis S, Fais F, Taiana E, Neri A, Bomben R, Gentile M, Gattei V, Ferrarini M, Morabito F, Fronza G.   +13 more
europepmc   +1 more source

New combinations of targeted therapies in melanoma [PDF]

, 2019
Inhibition des kinases Mnk1/2 pour éviter ou retarder les résistances aux thérapies ciblées dans le mélanome - Fédération Wallonie ...
Ghanem, Ghanem, Journe, Fabrice, Krayem, M, Saussez, Sven, Soumoy, Laura, Tagliatti, Vanessa   +5 more
core  

PTC596-Induced BMI-1 Inhibition Fights Neuroblastoma Multidrug Resistance by Inducing Ferroptosis. [PDF]

Antioxidants (Basel), 2023
Valenti GE, Roveri A, Venerando R, Menichini P, Monti P, Tasso B, Traverso N, Domenicotti C, Marengo B.   +8 more
europepmc   +1 more source

Mutant p53 talks to proteasomes—is there a feedback loop between Nrf2 and mutant p53? [PDF]

, 2016
Acedo Nunez, P, Zawacka-Pankau, J
core   +1 more source

2BA PRIMA-1met as a potential prostate cancer radiosensitizer under normoxia and hypoxia

European Journal of Cancer Supplements, 2007
S. Supiot, H. Zhao, K. Weiman, R.P. Hill, R.G. Bristow   +4 more
openaire   +1 more source