Results 271 to 280 of about 1,796,462 (350)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Factors associated with self-care behavior among heart failure patients in India: A systematic review. [PDF]

J Educ Health Promot
D'Souza PJJ, Lewis MS, Paramasivam G, Noronha JA, Kusumavathi P, Devasia T, George LS.   +6 more
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

An Ethical Reflection on Assisted Dying, Inequity Within Palliative Medicine Services and Access to Care in the United Kingdom: A Resident Doctor's Perspective. [PDF]

Cureus
Hayden MW.
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The Tacrine-Induced Endoplasmic Reticulum Stress in AChE-Expressed Cells Leads to Improper Assembly and Transport of the Oligomeric Enzyme: Reversal by Trehalose. [PDF]

J Neurochem
Wang X, Xia Y, Guo MS, Wu J, Dilidaer A, Gao J, Dong TT, Zhu Y, Tsim KWK.   +8 more
europepmc   +1 more source

Correction: Psychiatrist-led hepatitis C (HCV) treatment at an opioid agonist treatment clinic in Stockholm- a model to enhance the HCV continuum of care. [PDF]

BMC Psychiatry
Klasa PE, Sandell M, Aleman S, Kåberg M.   +3 more
europepmc   +1 more source

Logistics Management Information System (LMIS) for Health Commodities at Public Health Facilities in Amhara National Regional State of Ethiopia: A Data Quality Evaluation Survey [Letter]. [PDF]

J Multidiscip Healthc
Rashati D, Akbar PS.
europepmc   +1 more source

Role of Geriatric Assessment Scores as Predictors of Intensive Therapy Feasibility and Survival in Elderly Patients with Primary CNS Lymphoma. [PDF]

Cancers (Basel)
Isbell LK, Vreden A, Ihorst G, Uibeleisen R, Friedl A, Neumaier S, Wendler J, Orban A, Lauer EM, Fricker H, Malenica N, Illerhaus G, Schorb E.   +12 more
europepmc   +1 more source