Results 281 to 290 of about 1,796,462 (350)

Antitumor Effects of PRIMA-1 and PRIMA-1Met (APR246) in Hematological Malignancies: Still a Mutant P53-Dependent Affair?

open access: yesCells, 2021
Because of its role in the regulation of the cell cycle, DNA damage response, apoptosis, DNA repair, cell migration, autophagy, and cell metabolism, the TP53 tumor suppressor gene is a key player for cellular homeostasis.
Paola Menichini   +2 more
exaly   +2 more sources

Sustained Progression-Free Survival Benefit of Rituximab Maintenance in Patients With Follicular Lymphoma: Long-Term Results of the PRIMA Study

open access: yesJournal of Clinical Oncology, 2019
PURPOSE The PRIMA study (ClinicalTrials.gov identifier: NCT00140582) established that 2 years of rituximab maintenance after first-line immunochemotherapy significantly improved progression-free survival (PFS) in patients with follicular lymphoma ...
Emmanuel Bachy   +2 more
exaly   +2 more sources
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In silico and in vitro investigation of dual targeting Prima-1MET as precision therapeutic against lungs cancer

Journal of Biomolecular Structure and Dynamics, 2023
This study emphasizes the explorations of binding of Prima-1MET with two targets, p53 a tumor suppressor protein, and tyrosine kinase of epidermal growth factor receptor.
R. Meher, S. Mir, Siva Shanker Anisetti
semanticscholar   +1 more source

Analisa Faktor Yang Mempengaruhi Nyeri Haid (Dismenorhea) Pada Mahasiswa Akademi Kebidanan Prima Husada Bogor

Detector: Jurnal Inovasi Riset Ilmu Kesehatan, 2023
According to the World Health Organization (WHO), the incidence of dysmenorrhea reaches 90%. The prevalence is generally higher in young women in the 17 to 24 year age group, which is estimated at 60-90%.
Analisa Faktor   +14 more
semanticscholar   +1 more source

p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells

open access: yesJournal of Biological Chemistry, 2019
p53 mutants can form amyloid-like structures that accumulate in cells. p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) and its primary active metabolite, 2-methylene-3-quinuclidinone (MQ), can restore unfolded p53 mutants to a native ...
Jerson L Silva
exaly   +2 more sources

Pengaruh Stres Kerja, Komunikasi Kerja dan Kepuasan Kerja terhadap Prestasi Kerja Karyawan pada PT. Prima Karya Manunggal Kabupaten Pangkep

Āmār, 2022
Penelitian ini dilaksanakan pada pada PT. Prima Karya Manunggal Kabupaten Pangkep. Metode penelitian menggunakan pendekatan kuantitatif. Teknik pengumpulan data dengan menggunakan metode kuesioner.
Makkira Makkira   +4 more
semanticscholar   +1 more source

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