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The Journal of laboratory and clinical medicine, 1991
Although efficacy and toxicity of primaquine (PQ) depend on bioconversion, the process is poorly understood, even for carboxyprimaquine (CPQ), the major plasma metabolite. Earlier work to clarify drug metabolism showed that PQ could be converted quantitatively into CPQ, in vitro, with human erythroleukemic K562 cells or nonleukemic bone marrow ...
H, Frischer +3 more
openaire +1 more source
Although efficacy and toxicity of primaquine (PQ) depend on bioconversion, the process is poorly understood, even for carboxyprimaquine (CPQ), the major plasma metabolite. Earlier work to clarify drug metabolism showed that PQ could be converted quantitatively into CPQ, in vitro, with human erythroleukemic K562 cells or nonleukemic bone marrow ...
H, Frischer +3 more
openaire +1 more source
Primaquine revisited six decades after its discovery
European Journal of Medicinal Chemistry, 2009Nuno Vale, Rui Moreira, Paula Gomes
exaly