Results 181 to 190 of about 11,921,198 (227)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Fampridine for Symptomatic Treatment in Chronic Inflammatory Demyelinating Polyneuropathy: A Randomized, Double-Blinded, Placebo-Controlled Crossover Study. [PDF]

J Peripher Nerv Syst
Hansen PN, Markvardsen L, Tankisi H, Andersen H, Krøigård T, Sindrup S.   +5 more
europepmc   +1 more source

Strategy Selection and Outcomes of Tip-Detection in CTO-PCI: Intraplaque Tracking vs Antegrade Dissection and Re-Entry. [PDF]

JACC Adv
Yamaji K, Tanaka K, Yamasaki T, Tsutsui Y, Sudo K, Watanabe S, Iwamoto M, Tanaka N, Koyama Y, Iwanaga Y, Watanabe H, Fukumoto Y, Okamura A.   +12 more
europepmc   +1 more source

Letter to the Editor from Erdoğan Özbuğday and Karakurt: "Primary adrenal insufficiency resulting in diagnosis of rare <i>ABCD1</i> pathogenic variant in X-linked adrenoleukodystrophy". [PDF]

JCEM Case Rep
Erdoğan Özbuğday H, Karakurt F.
europepmc   +1 more source

Exploring spatial heterogeneity of PD-L1 and c-MET expression in oral squamous cell carcinoma. [PDF]

Oral Maxillofac Surg
Busse C, Hörner M, Saravi B, Haug L, Gubik S, Kübler A, Müller-Richter U, Rosenwald A, Hartmann S.   +8 more
europepmc   +1 more source