Results 1 to 10 of about 12,022 (141)

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

Inadvertent rupture of iridociliary cyst following transscleral Diode laser

Indian Journal of Ophthalmology, 2013
Primary iridociliary cysts can induce plateau iris configuration and angle closure glaucoma. We report a patient with bilateral, primary, ring-shaped, solitary iridociliary cysts.
Nikhil S Choudhari, Gangaprasad M Amula, Aditya Neog   +2 more
doaj   +1 more source

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source

Artificial Intelligence in Optical Coherence Tomography‐Based Ophthalmic Imaging: From Automated Diagnosis to Personalized Disease Monitoring

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is increasingly applied to optical coherence tomography (OCT) in ophthalmology, but evidence for automated diagnosis is stronger than evidence for longitudinal monitoring. This narrative review evaluates OCT‐based AI with emphasis on disease monitoring and progression, particularly in retinal disease and glaucoma ...
Stjepan Škudar
wiley   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Drug Utilization Study In Primary Glaucoma Patients Attending the Ophthalmology Outpatient Department of a Tertiary Care Hospital in Western Uttar Pradesh

Delhi Journal of Ophthalmology, 2017
Objective:- To evaluate prescription patterns for patients seeking consultation for various types and subtypes of primary glaucoma. Methods:- It was an observational study of one year duration.
Nazia Parween, Surabhi Gupta, Sanjiv Kumar, Kirti Jain, P.P. Khosla, Saurabh Kansal, Wase Khan   +6 more
doaj   +1 more source

Optic Nerve Thickness Assessed by Ocular Ultrasonography in Obstructive Sleep Apnea

Journal of Ultrasound in Medicine, EarlyView.
Objectives Obstructive sleep apnea (OSA) has been associated with various ocular complications, yet ultrasonographic evaluation of optic nerve thickness and its relationship with nocturnal hypoxemia remains poorly understood. This study aimed to evaluate optic nerve thickness and globe dimensions using ocular ultrasonography in patients with different ...
Buğra Kerget, Eyüp Çetin, Alperen Aksakal, Sırma Merve Çetin, Mustafa Buğra Coşkuner   +4 more
wiley   +1 more source

Advancing Artificial Intelligence in Myopia Management: From Predicting Progression to Supporting Clinical Decisions

Med Research, EarlyView.
The AI‐enabled multimodal framework for whole‐life myopia management. Graphical abstract illustrates the transition of myopia care from premyopia to myopia, high myopia, and pathologic myopia. Multimodal data, including demographic and refractive information, genetic, behavioral and environmental factors, ophthalmic imaging, and omics profiles, can be ...
Zewei Zhang, Yun Wang, Lifei Zhang, Dongmei Chen, Weijie Zhang, Fang Li, Jibo Zhou   +6 more
wiley   +1 more source

New Insights in Primary Angle Closure Glaucoma

Delhi Journal of Ophthalmology, 2010
Primary angle closure glaucoma is one of the major causes for irreversible visual loss in Asia. In addition to pupillary block, lens induced mechanisms, plateau iris and supra-ciliary effusions are important contributing factors eluciadated by Ultrasound
Tanuj Dada, Gaurav Kumar, Lalit Tejwani, Vishal Arora, Meenakshi Wadhwani, Anita Panda   +5 more
doaj   +1 more source

Association of Matrix Metalloproteinase-9 (MMP9) Variants with Primary Angle Closure and Primary Angle Closure Glaucoma. [PDF]

PLoS ONE, 2016
Shorter axial length observed in patients with primary angle closure glaucoma (PACG) might be due to altered matrix metalloproteinase-9 (MMP9) activity resulting in ECM remodeling during eye growth and development.
Xueli Chen, Yuhong Chen, Janey L Wiggs, Louis R Pasquale, Xinghuai Sun, Bao Jian Fan   +5 more
doaj   +1 more source