Results 91 to 100 of about 11,486 (208)

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik, Hua-Poo Su, Yacob Gomez Llorente, Rachel L. Palte, Daniel J. Klein, Robert P. Hayes, Sadie P. Antine, Guilermo A. Asmar-Rovira, Nicole Bertoletti, Noel J. Byrne, Brittany L. Carroll, Ciro D. Cordeiro, Kaylynn Curfman, James Dutko, Michael J. Eddins, Thierry Fischmann, Barani Govindarajan, Corey W. Hecksel, Thu Ho, Kaspar Hollenstein, Mee Ra Hong, Alan Hruza, Andrii Ishchenko, Maru Jaime-Garza, Matt J. Jaremko, Hayley L. Knox, James Kostas, Harini Krishnamurthy, Ioannis Manolaridis, Cameron L. Noland, Andrea T. Partridge, Sangita B. Patel, Paul Reichert, John C. Reid, Catarina Felisberto-Rodrigues, Chitra A. Shintre, Jennifer M. Shipman, Elakkiya Tamilselvan, Morgan E. Walker, Susanne N. Walker, Renjing Wang, Katharine M. Wright, Tien-Jui Yen, Byung-Kuk Yoo, Sandra B. Gabelli   +44 more
wiley   +1 more source

Anterior chamber flare and central macular thickness after trabeculectomy versus after phacoemulsification

Acta Ophthalmologica, Volume 104, Issue 4, Page 402-409, June 2026.
Abstract Purpose To compare the inflammatory response in the eye after trabeculectomy to after phacoemulsification, focusing on anterior chamber flare (AC flare) and central macular thickness (CMT). Methods Data from 436 participants in two randomized controlled trials were analysed.
Yasmeen Ahmed, Jesper Høiberg Erichsen, Afrouz Ahmadzadeh, Lars Morten Holm, Line Kessel, Daniella Bach‐Holm   +5 more
wiley   +1 more source

Primary open‐angle glaucoma as a marker of upcoming Alzheimer's disease: A 20‐year Danish National Registry‐Based Study

Acta Ophthalmologica, Volume 104, Issue 4, Page e426-e432, June 2026.
Abstract Purpose To investigate whether primary open‐angle glaucoma (POAG) is associated with an increased long‐term risk of developing Alzheimer's disease, given its shared neurodegenerative features. Methods A 20‐year longitudinal, registry‐based matched cohort study was conducted using Danish national health registries from 1998 to 2018. Individuals
Cecilia Kronvold, Signe Sperling, Sören Möller, Jakob Grauslund, Lonny Stokholm   +4 more
wiley   +1 more source

PRIMARY CREEPING ANGLE-CLOSURE GLAUCOMA [PDF]

British Journal of Ophthalmology, 1964
openaire   +2 more sources

Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on

Acta Ophthalmologica, Volume 104, Issue 4, Page e443-e452, June 2026.
Abstract Purpose The purpose of this study was to determine the disease course in patients with tubulointerstitial nephritis and uveitis (TINU) syndrome, focusing on long‐term outcome and the incidence of complications such as chronic kidney disease (CKD).
Jytte Hendrikse, Anne Sina Paula Simon, Viera Kalinina Ayuso, Joke Helena de Boer, Gerrit van den Berg   +4 more
wiley   +1 more source

Ocular surface disease in atopic dermatitis

Acta Ophthalmologica, Volume 104, Issue S291, Page S4-S28, June 2026.
ENGLISH SUMMARY Atopic keratoconjunctivitis (AKC) is a severe ocular surface disease (OSD) that significantly affects patients' quality of life and can lead to blindness. AKC is associated with atopic dermatitis (AD), a common chronic inflammatory skin disease affecting both children and adults.
Pernille May Hansen
wiley   +1 more source

Advancing Brain and Body Vascular Imaging in Bipolar Disorder: A Report From the International Society for Bipolar Disorders Vascular Task Force

Bipolar Disorders, Volume 28, Issue 4, June 2026.
ABSTRACT Objectives The heart–brain nexus is increasingly recognized as important for human health. Nonetheless, integration of this perspective in research and treatment remains limited in psychiatry, particularly in bipolar disorder (BD). Multisystem vascular imaging may help elucidate mechanisms linking heart and brain health in BD.
Megan Mio, Pao‐Huan Chen, Kody G. Kennedy, Hilary P. Blumberg, David J. Bond, Eric L. Goldwaser, Fabiano A. Gomes, Jody L. Greaney, Tomas Hajek, Susan L. McElroy, Roger S. McIntyre, Abigail Ortiz, Miguel L. Prieto, Elysha Ringin, Louisa G. Sylvia, Shang‐Ying Tsai, Jess G. Fiedorowicz, Benjamin I. Goldstein   +17 more
wiley   +1 more source

Therapeutic Peptide SS‐31 Modulates Membrane Binding and Aggregation of α‐Synuclein and Restores Impaired Mitochondrial Function

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
SS‐31 (Elamipretide) inhibits α‐synuclein aggregation on the membranes and emerges as a promising therapeutic candidate against mitochondrial dysfunction in Parkinson's disease. ABSTRACT Membrane binding and aggregation properties of α‐synuclein are closely associated with Parkinson's disease and a class of related syndromes named as synucleinopathy ...
Ewelina Stefaniak, Beiyuan Cui, Xucheng Yan, Kexin Sun, Xiangyu Teng, Liming Ying   +5 more
wiley   +1 more source

The role of ethnicity in primary angle-closure glaucoma.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1995
Primary angle-closure glaucoma is significantly more common than primary open-angle glaucoma in the East, whereas in Africa and Europe the reverse is true. In order to study the role of ethnic background in the frequency of primary angle-closure glaucoma in Cape Town and, in particular, in people of mixed ethnic background, the so-called 'coloureds ...
Salmon, J.F., Martell, R
openaire   +2 more sources

Adverse Drug Reaction Study of Botulinum Toxin‐A in the Real World

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Despite the increasing use of botulinum toxin type A (BoNT‐A) in aesthetic and therapeutic applications, its real‐world adverse drug reaction (ADR) profile remains incompletely characterized. Current evidence relies largely on small‐scale clinical observations rather than large, systematic analyses.
Jiaxu Gu, Yue Sun, Kexin Chen, Jieyi Wang, Bingcheng Lu, Hongqiang Xie, Xiaoming Liu, Cong Huang, Xingling Jian, Bo Yu   +9 more
wiley   +1 more source