Results 191 to 200 of about 6,908,138 (351)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Improving osteoarthritis diagnosis and management in the primary care setting: a concise educational tool for primary care providers. [PDF]

BMC Rheumatol
Morrison T, Giangregorio L, Hadley-Strout E, Gosselin J.   +3 more
europepmc   +1 more source

Primary Care Groups and Primary Care Trusts

Journal of the Royal College of Physicians of London, 1999
openaire   +2 more sources

Respiratory morbidity in children who had undergone primary repair of esophageal atresia with tracheo esophageal fistula in a tertiary care centre in India

, 2021
Madhan Kumar, Sneha Varkki, Sampath Karl, Harshjeet Singh Bal, Aparna Irodi, Mary John, Alok Rathi   +6 more
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Primary Medical Care [PDF]

BMJ, 1970
openaire   +2 more sources

PD21-03 ARE INDUSTRY PAYMENTS FOR TADALAFIL ASSOCIATED WITH PRESCRIBING HABITS AMONG UROLOGISTS AND PRIMARY CARE PHYSICIANS? [PDF]

, 2019
Kevin Lee Min Chua, Gen Li, Peter J. Stahl, Elias S. Hyams   +3 more
openalex   +1 more source

Medical Records Documentation of HIV/AIDS Clinical Services at Primary Health Care (PHC) Facilities and Its Implications on Continuum of Care and Operational Research in South Africa

, 2021
Henry Fomundam, Abraham Tesfay, S. A. Mushipe, H. T. Nyambi, Anthony K. Wutoh   +4 more
openalex   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Implementing Benzodiazepine Deprescribing in the Primary Care Clinic. [PDF]

JAMA Intern Med
Shuey B, Anderson TS, Park TW.
europepmc   +1 more source