Results 241 to 250 of about 6,908,138 (351)

Additional file 2 of Secondary care specialist visits made by children and young people prescribed antidepressants in primary care: a descriptive study using the QResearch database

, 2020
Ruth H. Jack, Rebecca M. Joseph, Carol Coupland, Debbie Butler, Chris Hollis, Richard Morriss, Roger Knaggs, Andrea Cipriani, Samuele Cortese, Julia Hippisley–Cox   +9 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Atrial fibrillation and primary care prevention and rehabilitation - a feasibility study. [PDF]

Pilot Feasibility Stud
Elnegaard CM, Pedersen MK, Zwisler AO, Borregaard B, Eilsø JF, Sommer T, Tveskov C, Hendriks JM, Brandes A, Risom SS.   +9 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Prevalence and predictors of prescribing errors in a primary care setting in Ghana. [PDF]

Ther Adv Drug Saf
Djochie RDA, Boakye-Yiadom J, Kwakye AO, Oppong KG, Mozu IE, Cobbold CC, Biney RP.   +6 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

The microbiome in mind: Reflections on antibiotic prescription in primary care. [PDF]

S Afr Fam Pract (2004)
Roos NDB.
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Difficult Doctor-Patient Relationships and Attachment Style in Primary Care. [PDF]

Healthcare (Basel)
Porcerelli JH, Eissa R, Morris P.
europepmc   +1 more source