Results 31 to 40 of about 5,707,579 (242)

Overcoming Challenges to Teamwork in Patient-Centered Medical Homes: A Qualitative Study [PDF]

, 2014
There is emerging consensus that enhanced inter-professional teamwork is necessary for the effective and efficient delivery of primary care, but there is less practical information specific to primary care available to guide practices on how to better ...
Amelia Bond, Ann S. O, Kevin Draper, Manasi Tirodkar, Rebecca Gourevitch   +4 more
core   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Reciprocal Learning and Chronic Care Model Implementation in Primary Care: Results from a New Scale of Learning in Primary Care [PDF]

, 2011
Efforts to improve the care of patients with chronic disease in primary care settings have been mixed. Application of a complex adaptive systems framework suggests that this may be because implementation efforts often focus on education or decision ...
Jordan, Michelle, Lanham, Holly, Leykum, Luci K., McDaniel, Reuben R., Noel, Polly H., Palmer, Ray, Parchman, Michael   +6 more
core   +2 more sources

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Primary Care Safety Net [PDF]

, 2003
Four community-based pilot projects for leveraging public-private partnerships to expand health care coverage among low-wage ...

core  

Counselling in primary care : a systematic review of the evidence [PDF]

, 2008
Primary objective: To undertake a systematic review which aimed to locate, appraise and synthesise evidence to obtain a reliable overview of the clinical effectiveness, cost-effectiveness and user perspectives regarding counselling in primary care. Main
Alison Brettle, Andy Hill, Arean P.A., Bellamy A., Chisholm D., Kates N., Kolk A., Mellor-Clark J., Murray G.C., Peter Jenkins, Ridsdale L.   +10 more
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Unique health care utilization patterns in a homeless population in Ghent [PDF]

, 2010
Background: Existing studies concerning the health care use of homeless people describe higher utilisation rates for hospital-based care and emergency care, and lower rates for primary care by homeless people compared to the general population.
Art, Bruno, De Maeseneer, Jan, Van de Walle, Mieke, VERDEE, TINE, Verlinde, Evelyn, Willems, Sara   +5 more
core   +3 more sources

Primary Care and Primary Care Training: Mirror Images [PDF]

Journal of General Internal Medicine, 2010
Primary care appears to be in a perpetual state of crisis. The failures are well known. Primary care physicians work in stressful, under-resourced work environments with overcrowded schedules geared towards acute care. Chronic disease patients receive inadequate treatment and physicians lack the time, expertise and money to systematically measure and ...
Eric J. Warm, Emily L. Leasure
openaire   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source