Results 41 to 50 of about 5,707,579 (242)

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Effect of spoken language on primary care choice refugee health assessment program patients seen at Boston Medical Center [PDF]

open access: yes, 2017
PURPOSE: There are approximately 21.3 million refugees worldwide. Connection to primary care is essential for these patients because of the potential for long-term and complex care that they require.
Tunstall, Hannah
core  

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

open access: yesMolecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever   +1 more
wiley   +1 more source

The role of primary care in adult weight management: qualitative interviews with key stakeholders in weight management services [PDF]

open access: yes, 2017
Background: Primary care has a key role to play in the prevention and management of obesity, but there remain barriers to engagement in weight management by primary care practitioners.
Blane, David N.   +3 more
core   +2 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink   +6 more
wiley   +1 more source

The Primary Care Cardiologist

open access: yesJournal of the American College of Cardiology, 2011
![Figure][1] From the time that I was an intern (which was some years ago), it was said that there was a shortage of primary care physicians. Over succeeding years this condition has worsened.
openaire   +3 more sources

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

open access: yesMolecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker   +14 more
wiley   +1 more source

Is bigger better for primary care groups and trusts? [PDF]

open access: yes, 2001
SIGLEAvailable from British Library Document Supply Centre-DSC:m01/16032 / BLDSC - British Library Document Supply CentreGBUnited ...
Bojke, C.   +4 more
core   +2 more sources

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

open access: yesMolecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen   +13 more
wiley   +1 more source

Palliative care in primary care: European Forum for Primary Care position paper [PDF]

open access: yesPrimary Health Care Research & Development, 2019
AbstractAim:The aim of this position paper is to assist primary health care (PHC) providers, policymakers, and researchers by discussing the current context in which palliative health care functions within PHC in Europe. The position paper gives examples for improvements to palliative care models from studies and international discussions at European ...
Rotar Pavlic, Danica   +5 more
openaire   +6 more sources

Home - About - Disclaimer - Privacy