Results 101 to 110 of about 1,395,505 (317)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

End-of-life decisions : a cross-national study of treatment preference discussions and surrogate decision-maker appointments [PDF]

, 2013
Background Making treatment decisions in anticipation of possible future incapacity is an important part of patient participation in end-of-life decision-making.
Evans, N.C., Natalie Evans, Bertolissi, S., Viviane Van Casteren, Pasman H. Roeline, Van Casteren, Viviane, Miccinesi, G., Pasman, H.R., Vega Alonso, Tomás, Block, L. van den, T. Vega Alonso, Onwuteaka-Philipsen, B.D., Van den Block, Lieve, Donker, Gé, S. Bertolissi, Bertolissi, Stefano, Pasman, H Roeline, Block, L., Evans, N., Stefano Bertolissi, Pasman, H.R.W., V. Van Casteren, Van den Block Lieve, Bregje Onwuteaka-Philipsen, Luc Deliens, ?, ?, Bertolissi Stefano, O. Zurriaga, Brearley, Sarah, Donker Gé, Gé Donker, Zurriaga, Oscar, Deliens, L., Onwuteaka-Philipsen, B., Viviane, V.C., Tomás Vega Alonso, Onwuteaka-Philipsen Bregje, H.R. Pasman, Donker, G., Oscar Zurriaga, van Casteren, V., Evans Natalie, L. Van den Block, EUROIMPACT, Miccinesi, Guido, Evans, Natalie, EUROIMPACT on behalf of, Lieve Van den Block, Miccinesi Guido, H Roeline Pasman, Deliens Luc, Zurriaga Oscar, B.D. Onwuteaka-Philipsen, N. Evans, L. Deliens, Deliens, Luc, Zurriaga, O., Vega Alonso Tomás, G. Miccinesi, Casteren, V. van, Onwuteaka-Philipsen, Bregje, Guido Miccinesi, Van Casteren Viviane, G.A. Donker, Alonso, T.V., Vega Alonso, T.   +65 more
core   +1 more source

Healthy eating and active living for diabetes in primary care networks (HEALD-PCN): rationale, design, and evaluation of a pragmatic controlled trial for adults with type 2 diabetes

BMC Public Health, 2012
BackgroundWhile strong and consistent evidence supports the role of lifestyle modification in the prevention and management of type 2 diabetes (T2DM), the best strategies for program implementation to support lifestyle modification within primary care ...
Steven T. Johnson, C. Mundt, A. Soprovich, Lisa A. Wozniak, R. Plotnikoff, Jeffrey A. Johnson   +5 more
semanticscholar   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Emerging models of integrated primary health care centres: how they optimise access and integration and the influence of characteristics and organisational factors

, 2015
Key messages > IPHCCs were providing access to a broader range of allied health, and in some cases medical specialist, services than traditional general practices. > IPHCC ownership and size were strong drivers of access arrangements.
Kearns, R ; https://orcid.org/, Powell Davies, G ; https://orcid.org/, Dennis, S ; https://orcid.org/, Spooner, C ; https://orcid.org/, Walker, C, Ward, B, Fuller, J, Russell, G, McDonald, J, Lane, R   +9 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

How to reform primary health care to close the gap [PDF]

, 2016
[Extract] Primary Health Networks were established in 2015 to reform the primary health-care system and better coordinate care across Australia. A range of services make up the primary care system in Australia. These include private general practices,
Couzos, Sophie
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

How do people with dementia utilise primary care physicians and specialists within dementia networks? Results of the Dementia Networks in Germany (DemNet-D) study.

Health and Social Care in the community, 2017
Outpatient dementia healthcare is predominantly fragmented, and dementia networks (DNs) represent an integrated care concept to overcome this problem.
M. Wübbeler, J. Thyrian, B. Michalowsky, P. Erdmann, Johannes Hertel, B. Holle, J. Gräske, S. Schäfer-Walkmann, W. Hoffmann   +8 more
semanticscholar   +1 more source

Links between systems in Accident & Emergency and primary care

Journal of Innovation in Health Informatics, 2005
The hospital emergency department and other elements of rapid access primary care constitute an emergency care network. Integration aims to maximise the network's strengths and overcome its weaknesses.
Nick Harrop
doaj   +1 more source