Results 81 to 90 of about 16,014 (252)

Advances in bronchiectasis:endotyping, genetics, microbiome, and disease heterogeneity [PDF]

, 2018
Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the radiographic demonstration of airway enlargement is the common feature of a heterogeneous set of conditions and clinical presentations.
Chalmers, James D., Flume, Patrick A., Olivier, Kenneth N.   +2 more
core   +2 more sources

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Modern Approaches to the Diagnosis and Management of Children With Primary Ciliary Dyskinesia

Педиатрическая фармакология, 2017
The article presents the most modern positions of healthcare delivery for children with primary ciliary dyskinesia. Symptoms of this pathology in clinical practice vary that is conditioned by genetic heterogeneity of the disease.
A. A. Baranov, L. S. Namazova-Baranova, E. A. Vishneva, L. R. Selimzyanova, O. I. Simonova, E. V. Sereda, N. N. Rozinova, E. N. Tzygina, L. K. Katosova, A. V. Lazareva, Yu. V. Gorinova, O. V. Kustova   +11 more
doaj   +1 more source

General and Specific Promotion of Flagellar Assembly by a Flagellar Nucleoside Diphosphate Kinase [PDF]

, 2017
Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the canonical NDK activity or alternative mechanisms that remain poorly defined.
Ciruelas, Kristine S., Diener, Dennis R., Gopal, Radhika, Ishikawa, Takashi, King, Stephen M., Liu, Yi, Maizy, Yousif, Poghosyan, Emiliya, Yang, Pinfen, Zhu, Xiaoyan   +9 more
core   +1 more source

A NIMA-related kinase suppresses the flagellar instability associated with the loss of multiple axonemal structures [PDF]

, 2015
CCDC39 and CCDC40 were first identified as causative mutations in primary ciliary dyskinesia patients; cilia from patients show disorganized microtubules, and they are missing both N-DRC and inner dynein arms proteins.
Chen, Fan, Dutcher, Susan K, Guo, Suyang, Kessler, Jonathan M, Lin, Huawen, Wang, Yan Mei, Zhang, Zhengyan   +6 more
core   +4 more sources

Situs Inversus Totalis: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT Situs Inversus Totalis (SIT) is a rare congenital anomaly characterized by the complete mirror‐image transposition of the thoracoabdominal viscera. Although typically it has a favorable prognosis, SIT can be associated with ciliopathy‐related disorders, most notably Primary Ciliary Dyskinesia (PCD).
Xin Du, Ning Wang, Juanjuan Sheng, Yunshan Zhang, Jinfang Gao   +4 more
wiley   +1 more source

Automating the measurement of physiological parameters: a case study in the image analysis of cilia motion [PDF]

, 2016
International audienceAs image processing and analysis techniques improve, an increasing number of procedures in bio-medical analyses can be automated.
Bequignon, E, Coste, A, Louis, B, Najman, Laurent, Papon, J.-F, Pelle, G, Puybareau, Élodie, Talbot, Hugues   +7 more
core   +4 more sources

Prenatal Exome Sequencing Analysis in Fetuses With Structural Anomalies: A Multicenter Prospective Cohort Study With Practical Implications

Prenatal Diagnosis, Volume 46, Issue 1, Page 46-55, January 2026.
ABSTRACT Objective To evaluate the diagnostic value of prenatal exome sequencing (ES) integrated with copy number variant (CNV) and single nucleotide variant (SNV) analysis (ES‐CNV/SNV) in fetuses with structural anomalies following negative chromosomal microarray analysis (CMA) and karyotyping, and to delineate the practical challenges encountered ...
Yulin Jiang, Haibo Li, Xiangyu Zhu, Liangpu Xu, Ying Chang, Fengqun Dong, Jianping Xiao, Jian Gao, Minyue Dong, Ying Peng, Hua Jin, Ting Wang, Xiaoxiao Xie, Lin Zhang, Hongmei Zhuang, Na Hao, Xiya Zhou, Hongna Wang, Ying You, Kun Ma, Rui Xiao, Qingwei Qi   +21 more
wiley   +1 more source

Airway Clearance Techniques for Primary Ciliary Dyskinesia; is the Cystic Fibrosis literature portable? [PDF]

, 2018
Primary Ciliary Dyskinesia (PCD) is a rare inherited disease with impaired mucociliary clearance. Airway clearance techniques (ACTs) are commonly recommended for patients with PCD to facilitate mucus clearance, despite a lack of evidence in this group ...
Barbato, Bush, Bush, Chevaillier, Cohen-Cymberknoh, Dell, Desai, El-Abiad, Ellerman, Farrell, Frownfelter, Gokdemir, Green, Gremmo, Irving, Jain, Kennedy, Kuehni, Lim, Lucas, Lucas, Lupton-Smith, McCarren, McManus, McShane, Miller, Narayan, Noone, Oxman, O’Callaghan, O’Donnell, Phillips, Prasad, Pryor, Sanderson, Schofield, Shah, Smyth, Strippoli, Valerio, van Der Schans, Werner, Whalley   +42 more
core   +1 more source

Exploring Exercise as Airway Clearance in Cystic Fibrosis: A Qualitative Study From the ExACT‐CF Feasibility Trial

Pediatric Pulmonology, Volume 61, Issue 1, January 2026.
ABSTRACT Question Cystic fibrosis (CF) affects > 11,300 people in the UK and is characterized by thick, sticky mucus in the lungs, leading to recurrent infections, inflammation, and progressive respiratory decline. Chest physiotherapy remains a cornerstone of airway clearance; however, many people with CF (pwCF) find it burdensome and time‐consuming ...
Emily Taylor, Dia Soilemezi, Don S. Urquhart, Steve Cunningham, Steff Lewis, Aileen Rae Neilson, Hannah Ensor, Ioannis Vogiatizis, Lorna Allen, Zoe L. Saynor, the ExACT‐CF study group, Don S. Urquhart, Emily Taylor, Steve Cunningham, Steff Lewis, Aileen Rae Neilson, Dia Soilemezi, Hannah Ensor, Ioannis Vogiatizis, Lorna Allen, Debbie Miller, Donna Bowen, Ellyse Kilarski, Ellen Lacey, Gary Connett, Julian Legg, Hazel Evans, Thomas Daniels, Mark Allenby, Mary Carroll, Robert Gray, Carlos Echevarria, Lisa Morrison, Gordon McGregor, Mary Abkir, Clare Saunders, Zoe L. Saynor   +36 more
wiley   +1 more source