Results 121 to 130 of about 4,977,244 (269)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

THE GENETIC BASIS OF PRIMARY ADULT-ONSET DYSTONIA

, 2011
Objectives. To identify novel genetic loci associated with primary adult-onset dystonia (AOD) and assess candidate genes from the literature. Secondary aimes.
Esposito, Marcello
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

CDC/DSTDP National Partners Collaborative on Public Health and Primary Care Integration for STD Prevention : Aug. 15\u201316, 2013, Meeting Summary, Atlanta, GA [PDF]

Achieving substantial and lasting improvements in the health of individuals and populations will require significant changes to the U.S. healthcare delivery system. Among these changes is the opportunity to better coordinate and, in some cases, integrate

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EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Review of primary frequency control requirements on the GB power system against a background of increasing renewable generation

, 2006
This thesis was submitted for the degree of Doctor of Engineering and awarded by Brunel University.The system frequency of a synchronous power system varies with the imbalance of energy supplied and the electrical energy consumed.
Pearmine, Ross
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Effectiveness of a provider and patient-focused intervention to improve hypertension management and control in the primary health care setting in Cuba : a controlled before-after study

, 2023
BackgroundImplementation research to improve hypertension control is scarce in Latin America. We assessed the effectiveness of an intervention aimed at primary care practitioners and hypertensive patients in a setting that provides integrated care ...
Carbonell García, Isabel, Battaglioli, Tullia, Van Der Stuyft, PatrickGE398010010174460009-0005-0895-1200F4E80C72-F0ED-11E1-A9DE-61C894A0A6B4, Smekens, Tom0020044646819190194521401f94513f-9c0f-11ec-976e-8d9c707756c4, Rodríguez Salvá, Armando, Achiong Estupiñán, Fernando, Díaz Piñera, Addys, Londoño Agudelo, Esteban AugustoUGent000181653112802003182242974988385149C721D632-914B-11E9-9F5B-CF1A5707D3EF   +7 more
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Identifying roles in smoking cessation care for different types of healthcare providers: a qualitative study with people who smoke

Frontiers in Health Services
ObjectiveThis study aimed to explore how people who smoke, in particular those with a lower socioeconomic position, perceive the roles of different healthcare providers in smoking cessation care.MethodsThree semi-structured focus groups were held with a ...
Naomi A. van Westen-Lagerweij, Elisabeth G. Meeuwsen, Esther A. Croes, Niels H. Chavannes, Eline Meijer   +4 more
doaj   +1 more source