Results 131 to 140 of about 1,503,702 (309)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Do primary energy resources influence industry location? [PDF]

By choosing to locate in a particular place, firms create employment opportunities for workers living there. And the wages they pay increase demand for local goods and services, creating additional job opportunities and further increasing the tax base ...
Michael J. Orlando, Jason P. Martinek
core  

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

The feasibility of long range battery electric cars in New Zealand

, 2009
New Zealand transport accounts for over 40% of the carbon emissions with private cars accounting for 25%. In the Ministry of Economic Development's recently released “New Zealand Energy Strategy to 2050”, it proposed the wide scale deployment of electric
Andrews, Deborah, Duke, Mike, Anderson, Timothy Nicholas   +2 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Influence of Photovoltaic Panel Parameters on the Primary Energy Consumption of a Low-Energy Building with an Air-Source Heat Pump—TRNSYS Simulations

Energies
The integration of photovoltaic systems with heat pumps can significantly influence primary energy consumption indicators and therefore plays a particularly important role in the low-energy construction sector.
Agata Ołtarzewska, Antonio Rodero Serrano, Dorota Anna Krawczyk   +2 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Energy efficiency improvement and GHG abatement in the global production of primary aluminium

, 2015
Primary aluminium production is a highly energy-intensive and greenhouse gas (GHG)-emitting process responsible for about 1 % of global GHG emissions. In 2009, the two most energy-intensive processes in primary aluminium production, alumina refining and ...
Energy, Resources & Technological Change, Energy and Resources, Worrell, Ernst, Kermeli, Katerina, Crijns - Graus, Wina, Ter Weer, Peter Hans   +5 more
core   +1 more source

Chemosynthetic symbiont with a drastically reduced genome serves as primary energy storage in the marine flatworm Paracatenula. [PDF]

Proc Natl Acad Sci U S A, 2019
Jäckle O, Seah BKB, Tietjen M, Leisch N, Liebeke M, Kleiner M, Berg JS, Gruber-Vodicka HR.   +7 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source