Results 31 to 40 of about 147,812 (217)

Lipid-based protein sparing in juvenile whiteleg shrimp (Penaeus vannamei Boone, 1931) under reduced-protein diets and the limits of functional additives

Frontiers in Aquaculture
Dietary protein is the primary cost and environmental driver of shrimp feeds, motivating efforts to enhance protein utilization through lipid substitution and functional additives.
Joren Alutaya, Brett Laudato, Jaynos R. Cortes   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Moderate ethanol exposure disrupts energy homeostasis between central and peripheral system in APP/PS1 mice

Molecular Brain
To investigate the effects of moderate ethanol exposure on glucose metabolism in APP/PS1 mice, an early-onset Alzheimer’s disease (AD) mouse model, we employed an fluoro-deoxy-glucose (FDG)-micro-positron emission tomography (PET).
Shinwoo Kang, Jeyeon Lee, Paul H. Min, Doo-Sup Choi   +3 more
doaj   +1 more source

Charge Characteristics of Agouti-Related Protein Implicate Potent Involvement of Heparan Sulfate Proteoglycans in Metabolic Function

iScience, 2019
Summary: The endogenous melanocortin peptide agouti-related protein (AgRP) plays a well-known role in foraging, but its contribution to metabolic regulation is less understood.
Jihuan Chen, Valerie Chen, Tomoya Kawamura, Ivy Hoang, Yang Yang, Ashley Tess Wong, Ryan McBride, Vez Repunte-Canonigo, Glenn L. Millhauser, Pietro Paolo Sanna   +9 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Inherent spatiotemporal uncertainty of renewable power in China

Nature Communications, 2023
Solar and wind resources are vital for the sustainable energy transition. Although renewable potentials have been widely assessed in existing literature, few studies have examined the statistical characteristics of the inherent renewable uncertainties ...
Jianxiao Wang, Liudong Chen, Zhenfei Tan, Ershun Du, Nian Liu, Jing Ma, Mingyang Sun, Canbing Li, Jie Song, Xi Lu, Chin-Woo Tan, Guannan He   +11 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Impact assessment of Chinese mitten crab polyculture on saline-alkali rice fields based on food web models

Aquaculture Reports
In China, the introduction of Chinese mitten crabs Eriocheir sinensis into saline-alkali rice fields has improved both soil utilization and quality. To promote the development and adoption of this novel rice-cropping mode, this study developed Ecopath ...
Liang Yue, Shipeng Dong, Feng Liu, Dapeng Liu, Hongwei Shan, Fang Wang   +5 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source