Results 151 to 160 of about 19,641,486 (386)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Developing a digital phenotype to subdivide adult immunosuppressed COVID-19 outcomes within the English Primary Care Sentinel Network

Frontiers in Immunology
BackgroundAdults classified as immunosuppressed have been disproportionately affected by the COVID-19 pandemic. Compared to the immunocompetent, certain patients are at increased risk of suboptimal vaccine response and adverse health outcomes if infected.
Meredith Leston, Debasish Kar, Anna Forbes, Gavin Jamie, Rashmi Wimalaratna, Gunjan Jiwani, José M. Ordóñez-Mena, Daniel E. Stewart, Daniel E. Stewart, Heather Whitaker, Mark Joy, Lennard Y. W. Lee, F. D. Richard Hobbs, Simon de Lusignan   +13 more
doaj   +1 more source

Damping of ship-induced primary waves in groyne fields

, 2021
Environmental Fluid ...
Pasman, R. (author), Schielen, R.M.J. (author), Bricker, J.D. (author), van der Hout, A.J. (author), Mosselman, E. (author), Uijttewaal, W.S.J. (author), Collas, Frank (author), Huthoff, Freek (author)   +7 more
openaire   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Pre-School Teachers in Primary Schools: Stories from the Field [PDF]

, 2000
Abigail Sawyer
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Measles Outbreak in Lambu Internally Displaced Persons´ Camp, Maiduguri, Borno State, Nigeria, 2017

Journal of Interventional Epidemiology and Public Health
Introduction: Measles, a highly infectious disease caused by the Measles virus, is endemic in Nigeria. Although children are vaccinated against measles at the age of nine months which has led to a significant reduction in morbidity and mortality ...
Taiwo Israel Olasoju, Mary Idowu Olasoju, Batula Bishara Daggash, Bio Belu Abaye, Chibuike Enumah, Salisu Isah1, Mohammed Tahiru Bolori, Oluwawemimo Oluseun Adebowale   +7 more
doaj   +1 more source

Interspike Intervals, Receptive Fields, and Information Encoding in Primary Visual Cortex [PDF]

, 2000
Daniel S. Reich, Ferenc Mechler, Keith P. Purpura, Jonathan D. Victor   +3 more
openalex   +1 more source

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

p–primary part of the Milnor K–groups and Galois cohomologies of fields of characteristic p [PDF]

, 2000
Oleg Izhboldin
openalex   +1 more source