Results 101 to 110 of about 1,382,969 (293)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A new perspective on frequency control in conventional and future interconnected power systems

International Journal of Electrical Power & Energy Systems
In the interconnected power systems, the frequency change during disturbances may manifest differently in certain areas in the initial moments after the disturbance. Due to wave propagation, generating units located in distant areas contribute to primary
Tomislav Baškarad, Ninoslav Holjevac, Igor Kuzle   +2 more
doaj   +1 more source

The cytolytic T lymphocyte response to the murine cytomegalovirus [PDF]

, 1984
Limiting dilution (LD) analysis with two modifications, the expansion and the restimulation LD assay, led to the detection and quantification of two distinct in vivo maturation stages within the lineage of virus- specific self-restricted CTL after ...
Reddehase, Matthias J., Koszinowski, Ulrich H., Keil, Günther M.   +2 more
core  

Timing precision in population coding of natural scenes in the early visual system [PDF]

, 2008
The timing of spiking activity across neurons is a fundamental aspect of the neural population code. Individual neurons in the retina, thalamus, and cortex can have very precise and repeatable responses but exhibit degraded temporal precision in response
Chong Weng, Jin, Jianzhong, Desbordes, Gaëlle, Jose-Manuel Alonso, Weng, Chong, Stanley, Garrett B., Lesica Nicholas A, Alonso Jose-Manuel, Lesica, Nicholas A., Jin Jianzhong, Jianzhong Jin, Alonso, Jose-Manuel, Desbordes Gaëlle, Garrett B Stanley, Nicholas A Lesica, Gaëlle Desbordes, Weng Chong, Stanley Garrett B   +17 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Frequency response reduced order model of primary resonance of electrostatically actuated MEMS circular plate resonators [PDF]

, 2017
This paper deals with the amplitude-frequency response of soft AC electrostatically actuated MEMS clamped circular plates. Alternating Current (AC) frequency is near half natural frequency of the plate.
Caruntu, Dumitru I., Oyervides, Reynaldo
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The frequency of Celiac disease in primary Sjögren’s syndrome [PDF]

Objective: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands, affecting many organs.
Özlem Özdemir Işık, Senem Tekeoğlu, Ayşe Çefle, Murat Öztürkler, Duygu Temiz Karadağ, Ayten Yazıcı   +5 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A CORF computational model of a simple cell that relies on LGN input outperforms the Gabor function model [PDF]

, 2012
Simple cells in primary visual cortex are believed to extract local contour information from a visual scene. The 2D Gabor function (GF) model has gained particular popularity as a computational model of a simple cell.
Azzopardi, George,, Petkov, Nicolai, George Azzopardi, Nicolai Petkov, Petkov, Nicolai,, Azzopardi, George, Azzopardi, George; id_orcid   +6 more
core   +1 more source