Results 131 to 140 of about 3,140,596 (304)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Analysis and Control Parameters Optimization of Wind Turbines Participating in Power System Primary Frequency Regulation with the Consideration of Secondary Frequency Drop

Energies
With the increasing integration of wind energy into power systems, maintaining frequency stability has become a significant challenge. To address the issue of secondary frequency drop caused by wind turbines exiting the primary frequency regulation of ...
Ketian Liu, Zhengxi Chen, Xiang Li, Yi Gao   +3 more
doaj   +1 more source

Primary Frequency Response and Control of Power System Frequency

, 2018
This report is a supplement to the report Frequency Control Requirements for Reliable Interconnection Frequency Response. To see the main report and all of its supplemental materials, visit https://certs.lbl.gov/project/interconnection-frequency-response.
openaire   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Co-Optimization of Ancillary Services Providing Primary Frequency Control in the Day-Ahead Market

IEEE Access
Large-scale integration of inverter-based resources (IBRs) challenges primary frequency control because IBRs don’t typically respond to frequency fluctuations, which is partially due to a lack of financial incentives.
Manuel Garcia, J. Kyle Skolfield, Felipe Wilches-Bernal, Ross Baldick   +3 more
doaj   +1 more source

Cost-effective primary frequency response at high asynchronous generation levels

, 2013
Restrained generation from wind and solar PV can provide a frequency response that is fast in comparison to conventional generation. However, the reduced inertia in a dispatch with little conventional generation can cause very fast initial drop in the frequency and it may be difficult to mitigate that with wind and solar PV alone.
van Hulle, Frans, Gubina, Andrej, Cutululis, Nicolaus, Kiviluoma, Juha   +4 more
openaire   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Some aspects of optical feedback with cadmium sulfide and related photoconductors [PDF]

A primary limitation of many solid state photoconductors used in electro-optical systems is their slow response in converting varying light intensities into electrical signals.
Katzberg, S. J.
core   +1 more source

Air gap influence on the vibro-acoustic response of Solar Arrays during launch [PDF]

, 2010
One of the primary elements on the space missions is the electrical power subsystem, for which the critical component is the solar array. The behaviour of these elements during the ascent phase of the launch is critical for avoiding damages on the ...
Chimeno Manguan, Marcos, Fernandez, M.J., García Echebarria, J., López Díez, Jesús, Santiago Prowald, Julián B., Simon, F., Wijker, J.J.   +6 more
core   +1 more source