Results 1 to 10 of about 81,855 (113)

Lung transplantation from polytrauma donors: beyond primary graft dysfunction [PDF]

Frontiers in Medicine
BackgroundLung donors are increasingly older and marginal. Polytrauma donors (PD) represent a potentially valuable resource due to their younger age, although trauma-related lung injury raises concerns regarding graft quality.
Chiara Catelli, Daniele Marianello, Andrea Lloret Madrid, Marianna Rizzo, Miriana D'Alessandro, Margherita Sambo, Francesca Montagnani, Marco Guerrieri, David Bennett, Elena Bargagli, Piero Paladini, Federico Franchi, Luca Luzzi   +12 more
doaj   +2 more sources

Primary graft dysfunction prevention strategies in the perioperative period [PDF]

JHLT Open
Background: Primary graft dysfunction (PGD) remains a leading cause of early morbidity and mortality after heart and lung transplantation. It results from a multifactorial process involving ischemia–reperfusion injury, inflammatory and immune responses ...
Jérémie Guillemin, MD, Michael Cutrone, DO, Suraj Yalamuri, MD, Monica Arndt, MD, Adrien Bouglé, MD, PhD, Sharon L. McCartney, MD, FASE   +5 more
doaj   +2 more sources

Risk Factors for Severe Primary Graft Dysfunction in Infants Following Heart Transplant

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Previous studies suggest that infant heart transplant (HT) recipients are at higher risk of developing severe primary graft dysfunction (PGD) than older children.
Tajinder P. Singh, Elizabeth L. Profita, Peter Rycus, Ravi Thiagarajan, Kimberlee Gauvreau   +4 more
doaj   +3 more sources

Risk factors for primary graft dysfunction after heart transplantation—a systematic review and meta-analysis [PDF]

JHLT Open
Background: Primary graft dysfunction (PGD) is an important contributor to early mortality after heart transplantation (HTX). The International Society for Heart and Lung Transplantation (ISHLT) published a consensus definition of primary graft ...
Mats T. Vervoorn, MD, PhD, Selma E. Kaffka genaamd Dengler, MD, PhD, Elisa M. Ballan, MSc, Jord F. Kernkamp, BSc, Mudit Mishra, PhD, Sue A. Braithwaite, MD, Marish I.F.J. Oerlemans, MD, PhD, Niels P. van der Kaaij, MD, PhD   +7 more
doaj   +2 more sources

Incidence, predictors and outcomes following primary graft dysfunction after cardiac transplantation [PDF]

Transplant International
Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after heart transplantation (HTx). We retrospectively analyzed 830 consecutive HTx performed between 1984 and 2021. After excluding patients <18 years and those with
Isabella Lepore, Isabella Lepore, Jonatan Oras, Andreas Wallinder, Maria Tholén, Maria Tholén, Aldina Pivodic, Aldina Pivodic, Göran Dellgren, Göran Dellgren, Göran Dellgren   +10 more
doaj   +2 more sources

Donor lung weight a novel predictor for primary graft dysfunction [PDF]

JHLT Open
Background: Primary graft dysfunction (PGD) remains a leading cause of early morbidity and mortality in lung transplantation. PGD is characterized by diffuse alveolar damage and the accumulation of extravascular lung water in the transplanted lung.
Andreas Martinsson, MD, Anders Thoren, MD, PhD, Sven-Erik Ricksten, MD, PhD, Jonatan Oras, MD, PhD, Moustafa Mohsen Abed, MD, Petra Vestlund, CTC, Jesper M. Magnusson, MD, PhD, Andreas Wallinder, MD, PhD   +7 more
doaj   +2 more sources

Primary graft dysfunction in heart transplantation: the challenge to survival [PDF]

Journal of Cardiothoracic Surgery
Primary graft dysfunction (PGD) is a life-threatening clinical condition with a high mortality rate, presenting as left, right, or biventricular dysfunction within the initial 24 h following heart transplantation, in the absence of a discernible ...
Hüseyin Sicim, Wing Sum Vincy Tam, Paul C. Tang   +2 more
doaj   +2 more sources

Reduction of primary graft dysfunction using cytokine adsorption during organ preservation and after lung transplantation

Nature Communications, 2022
Lung transplantation is hindered by the scarcity of organs and by mortality following primary graft dysfunction. Here, the authors show that cytokine absorption can be used in donor lungs during ex vivo lung perfusion and post-transplant, and leads to ...
Haider Ghaidan, Martin Stenlo, Anna Niroomand, Margareta Mittendorfer, Gabriel Hirdman, Nika Gvazava, Dag Edström, Iran A. N. Silva, Ellen Broberg, Oskar Hallgren, Franziska Olm, Darcy E. Wagner, Leif Pierre, Snejana Hyllén, Sandra Lindstedt   +14 more
doaj   +1 more source

Ischemia-reperfusion Injury in the Transplanted Lung: A Literature Review

Transplantation Direct, 2021
Lung ischemia-reperfusion injury (LIRI) and primary graft dysfunction are leading causes of morbidity and mortality among lung transplant recipients. Although extensive research endeavors have been undertaken, few preventative and therapeutic treatments ...
Tara Talaie, MD, MS, Laura DiChiacchio, MD, PhD, Nikhil K. Prasad, MB, ChB, Chetan Pasrija, MD, Walker Julliard, MD, David J. Kaczorowski, MD, Yunge Zhao, MD, PhD, Christine L. Lau, MD   +7 more
doaj   +1 more source

Current status and outcomes in heart transplantation: a narrative review [PDF]

Reviews in Cardiovascular Medicine, 2022
The first human heart transplantation was performed by Christian Barnard in 1967. While the technical aspect had been worked out, allograft rejection was a major limitation in the early days of heart transplant.
Morcos A. Awad, Aakash Shah, Bartley P. Griffith   +2 more
doaj   +1 more source