Results 91 to 100 of about 126,407 (290)

IL-1β–dependent extravasation of preexisting lung-restricted autoantibodies during lung transplantation activates complement and mediates primary graft dysfunction

open access: yesThe Journal of Clinical Investigation, 2022
Preexisting lung-restricted autoantibodies (LRAs) are associated with a higher incidence of primary graft dysfunction (PGD), although it remains unclear whether LRAs can drive its pathogenesis.
Wenbin Yang   +15 more
doaj   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

open access: yesAdvanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji   +7 more
wiley   +1 more source

Early liver allograft dysfunction: risk factors, clinical course and outcomes

open access: yesТрансплантология (Москва), 2016
Early liver allograft dysfunction (EAD) is associated with a high incidence of graft loss and patient mortality in the first 6 weeks after orthotopic liver transplantation (OLT).The aim of this retrospective single-center study is to identify the risk ...
Ya. G. Moysyuk   +5 more
doaj  

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

open access: yesAdvanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández   +4 more
wiley   +1 more source

Improvement of lung preservation - From experiment to clinical practice [PDF]

open access: yes, 2002
Background. Reperfusion injury represents a severe early complication following lung transplantation. Among the pathogenetic factors, the high potassium content of Euro-Collins(R) solution is discussed.
Bittmann, I.   +7 more
core   +1 more source

Primary Graft Dysfunction Following Heart Transplantation: A Modern Review of Primary Graft Dysfunction

open access: yesThe Heart Surgery Forum
Primary graft dysfunction (PGD) represents a poor prognostic outcome for patients undergoing orthotopic heart transplantation (OHT). The risk factors associated with PGD are multifactorial and complex, encompassing factors related to the donor, recipient, and preservation.
Tadahisa Sugiura   +6 more
openaire   +1 more source

Smart Catheters for Diagnosis, Monitoring, and Therapy

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman   +12 more
wiley   +1 more source

Orthotopic liver transplantation in human-immunodeficiency-virus-positive patients in Germany [PDF]

open access: yes, 2012
Objectives: This summary evaluates the outcomes of orthotopic liver transplantation (OLT) of HIV-positive patients in Germany. Methods: Retrospective chart analysis of HIV-positive patients, who had been liver-transplanted in Germany between July ...
Anadol, Evrim   +15 more
core   +2 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

open access: yesAdvanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales   +11 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

open access: yesAdvanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu   +21 more
wiley   +1 more source

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