Results 141 to 150 of about 81,954 (212)

Respiratory Viruses at Time of Lung Transplant and the Relationship to Primary Graft Dysfunction. [PDF]

Transpl Infect Dis
van den Bosch L, Kaur K, Varughese R, Hirji A, Weatherald J, Weinkauf J, Lien D, Garcia OF, Alvarez CC, Doucette K, Kabbani D, Halloran K.   +11 more
europepmc   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

Impact of preoperative left ventricular diastolic dysfunction on primary graft dysfunction and mortality following lung transplantation. [PDF]

J Thorac Dis
Tang S, Feng X, Hua J, Chen M, Wang K, Miao S, Xu J, Dai M, Gu S, Liang X, Qian Y, Hu C, Huang D.   +12 more
europepmc   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Optimization of pretransplant amiodarone therapy to prevent primary graft dysfunction following heart transplantation. [PDF]

JHLT Open
Kwon YIC, Keller M, Lai A, Ambrosio M, Patel J, Fox K, Tchoukina IF, Shah KB, Fitch Z, Chery J, Quader M, Nicolato P, Kasirajan V, Hashmi ZA.   +13 more
europepmc   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Primary graft dysfunction in donor after brain death vs normothermic regional perfusion heart transplants. [PDF]

JHLT Open
Vu Maffei M, Kozuch JM, Mariski M, Philbrick M, Topik A, Azar F, Cole J, Urey MA, Pretorius V, Kearns MJ, Hong KN.   +10 more
europepmc   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Double whammy: increased severe primary graft dysfunction after prolonged warm ischemia and inadequate oxygen delivery during heart transplant. [PDF]

Front Transplant
Wang CC, Ahmad A, Petrovic M, Navid W, Eidson C, Trahanas J, Williams AM, Bommareddi S, Nguyen DQ, Absi T, Quintana E, DeVries S, Lepore JA, Warhoover M, Rali AS, Schlendorf KH, Bacchetta M, Shah AS, Lima B.   +18 more
europepmc   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source