Results 181 to 190 of about 126,407 (290)

Short airway telomeres are associated with primary graft dysfunction and chronic lung allograft dysfunction. [PDF]

J Heart Lung Transplant, 2023
Greenland JR, Guo R, Lee S, Tran L, Kapse B, Kukreja J, Hays SR, Golden JA, Calabrese DR, Singer JP, Wolters PJ.   +10 more
europepmc   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

Use of Impella RP Flex in Post-Heart Transplant Patients with RV Primary Graft Dysfunction. [PDF]

Biomedicines
Dumitru I, DeWolf J, Sevillano M, Schnell L, Bezerra H, Rinde-Hoffman D.   +5 more
europepmc   +1 more source

Predictors of early graft outcome in liver transplantation [PDF]

, 1996
, JR Doyle HR, Aldrighetti, L, Doria, C, Gayowski, TJP, Madariaga,, Marino, IR, Morelli, F, Starzl, TE   +7 more
core  

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Veno-venous versus Veno-arterial extracorporeal membrane oxygenation for the management of primary graft dysfunction following lung transplantation: A systematic review and meta-analysis. [PDF]

JHLT Open
Carvalho EA, Coelho BC, da Nobrega Oliveira REN, Delgado LM, Passos FS, Caldonazo T, Cypel M.   +6 more
europepmc   +1 more source

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

Biomarkers for primary graft dysfunction after lung transplantation: a review of current evidence and future prospects. [PDF]

Front Physiol
Feng L, Luo K, Qiu Y, Li R, Xue C, Xi S, Liu J, Pei Y, Ma C.   +8 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Allogeneic mesenchymal stromal cell therapy on primary graft dysfunction after lung transplantation. [PDF]

JHLT Open
Qayyum AA, Lund TK, Jensen PB, Jensen K, Haack-Sørensen M, Ekblond A, Nørgaard MJ, Møller-Sørensen H, Mathiasen AB, Møller CH, Rørvig SB, Kalhauge A, Bruunsgaard H, Litman T, Johansen EM, Højgaard LD, Kastrup J, Perch M.   +17 more
europepmc   +1 more source