Results 221 to 230 of about 126,407 (290)

Analysis of Primary Graft Dysfunction (PGD) Risk Factors in Lung Transplantation (LuTx) Patients. [PDF]

Clin Pract
Kubisa MJ, Wojtyś ME, Lisowski P, Kordykiewicz D, Piotrowska M, Wójcik J, Pieróg J, Safranow K, Grodzki T, Kubisa B.   +9 more
europepmc   +1 more source

Allospecificity of liver allograft-derived lymphocytes and correlation with clinicopathologic findings [PDF]

, 1988
Demetris, AJ, Duquesnoy, RJ, Fung, JJ, Markus, BH, Saidman, S, Starzl, TE, Zeevi, A   +6 more
core  

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

Advanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao, Xiaoli Cui, Huizhu Du, Zhuoqun Wang, Chang Liu, Linxin Zhang, Jianing Qi, Di Yang, Hui Yu, Shuang Yan, Wei Liu, Haiming Sun, Mengyang Wang   +12 more
wiley   +1 more source

Contrasting predictors of severe primary graft dysfunction following transplant for chronic and acute respiratory failure. [PDF]

J Thorac Dis
Kurihara C, Kaiho T, Thomae B, Cerier E, Lung K, Avella Patino D, Toyoda T, Yan Y, Budinger GRS, Bharat A.   +9 more
europepmc   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Differentially expressed microRNAs in pre-transplant lung biopsies target immune checkpoint proteins and can predict primary graft dysfunction in lung transplantation. [PDF]

Heliyon
Miceli V, Ferrigno P, Centi C, Carcione C, Iannolo G, Agnese V, Lo Iacono G, Liotta R, Conaldi PG, Pinzani M, De Monte L, Bertani A.   +11 more
europepmc   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Long-term air pollution exposure and the risk of primary graft dysfunction after lung transplantation. [PDF]

J Heart Lung Transplant
Koyama T, Zhao Z, Balmes JR, Calfee CS, Matthay MA, Reilly JP, Porteous MK, Diamond JM, Christie JD, Cantu E, Ware LB, Lung Transplant Outcomes Group.   +11 more
europepmc   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Peripheral versus central cannulation of VA-ECMO for primary graft dysfunction after heart transplantation: A systematic review and meta-analysis. [PDF]

JHLT Open
Ródenas-Alesina E, Olivella A, Orchanian-Cheff A, Foroutan F, Moayedi Y, Rao V, Billia F, Ross HJ, Alba AC, Aleksova N.   +9 more
europepmc   +1 more source