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Seminars in Respiratory and Critical Care Medicine, 2021
AbstractPrimary graft dysfunction (PGD) is a form of acute lung injury after transplantation characterized by hypoxemia and the development of alveolar infiltrates on chest radiograph that occurs within 72 hours of reperfusion. PGD is among the most common early complications following lung transplantation and significantly contributes to increased ...
Jake G, Natalini, Joshua M, Diamond
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AbstractPrimary graft dysfunction (PGD) is a form of acute lung injury after transplantation characterized by hypoxemia and the development of alveolar infiltrates on chest radiograph that occurs within 72 hours of reperfusion. PGD is among the most common early complications following lung transplantation and significantly contributes to increased ...
Jake G, Natalini, Joshua M, Diamond
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Clinics in Chest Medicine, 2009
Primary graft dysfunction (PGD) is the most important cause of early morbidity and mortality following lung transplantation. PGD affects up to 25% of all lung transplant procedures and currently has no proven preventive therapy. Lung transplant recipients who recover from PGD may have impaired long-term function and an increased risk of bronchiolitis ...
James C, Lee, Jason D, Christie
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Primary graft dysfunction (PGD) is the most important cause of early morbidity and mortality following lung transplantation. PGD affects up to 25% of all lung transplant procedures and currently has no proven preventive therapy. Lung transplant recipients who recover from PGD may have impaired long-term function and an increased risk of bronchiolitis ...
James C, Lee, Jason D, Christie
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Current Opinion in Organ Transplantation, 2007
Primary graft dysfunction is the major determinant of early morbidity and mortality after lung transplantation. Survivors of primary graft dysfunction have a protracted recovery and worse long-term mortality in ensuing years. Furthermore, primary graft dysfunction survivors may have a greater risk of bronchiolitis obliterans syndrome.
Seth A Hoffman +2 more
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Primary graft dysfunction is the major determinant of early morbidity and mortality after lung transplantation. Survivors of primary graft dysfunction have a protracted recovery and worse long-term mortality in ensuing years. Furthermore, primary graft dysfunction survivors may have a greater risk of bronchiolitis obliterans syndrome.
Seth A Hoffman +2 more
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Primary graft dysfunction after liver transplantation
Hepatobiliary & Pancreatic Diseases International, 2014Primary graft dysfunction (PGD) causes complications in liver transplantation, which result in poor prognosis. Recipients who develop PGD usually experience a longer intensive care unit and hospital stay and have higher mortality and graft loss rates compared with those without graft dysfunction.
Xiao-Bo, Chen, Ming-Qing, Xu
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Primary graft dysfunction in heart transplantation
Current Opinion in Organ Transplantation, 2018Primary graft dysfunction (PGD) is common early postheart transplantation; however, use of standardized definitions remains inconsistent. This review focuses on understanding the incidence, classification, risk factors, and management of PGD.The incidence and mortality of PGD in heart transplant varies considerably in the published literature ranging ...
Eugene C, DePasquale, Abbas, Ardehali
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Primary Graft Dysfunction After Lung Transplantation
Clinics in Chest Medicine, 2017Primary graft dysfunction is a form of acute injury after lung transplantation that is associated with significant short- and long-term morbidity and mortality. Multiple mechanisms contribute to the pathogenesis of primary graft dysfunction, including ischemia reperfusion injury, epithelial cell death, endothelial cell dysfunction, innate immune ...
Mary K, Porteous, James C, Lee
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Primary graft dysfunction after lung transplantation
Medicina Intensiva (English Edition), 2012Lung transplantation is a therapeutic option for pulmonary diseases in which the other treatment options have failed or in cases of rapid disease progression. However, transplantation is not free from complications, and primary graft dysfunction is one of them. Primary graft dysfunction is a form of acute lung injury.
V J, Suárez López +3 more
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Primary Graft Dysfunction in Lung Transplantation
Seminars in Respiratory and Critical Care Medicine, 2006Following the initial successful lung transplants reported by the Toronto Lung Transplant Group in 1986, lung transplantation has evolved into an effective treatment of isolated pulmonary failure and has been performed in more than 20,000 recipients. Increased experience, adjustments, and additions to the surgical technique and improved perioperative ...
Yvonne Marie, Carter, R Duane, Davis
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Primary Graft Dysfunction (PGD) Following Lung Transplantation
Seminars in Respiratory and Critical Care Medicine, 2018Abstract Primary graft dysfunction (PGD) is a form of acute lung injury that results from ischemia reperfusion injury (IRI) and is the major cause of early posttransplant morbidity and mortality. Patients who survive PGD have decreased quality of life, an increased risk of chronic lung allograft dysfunction, specifically bronchiolitis
Rupal J, Shah, Joshua M, Diamond
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Plasma kallikrein predicts primary graft dysfunction after heart transplant
The Journal of Heart and Lung Transplantation, 2021Primary graft dysfunction (PGD) is the leading cause of early mortality after heart transplant. Pre-transplant predictors of PGD remain elusive and its etiology remains unclear.Microvesicles were isolated from 88 pre-transplant serum samples and underwent proteomic evaluation using TMT mass spectrometry.
Giangreco, Nicholas +13 more
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