Results 171 to 180 of about 6,981,203 (402)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Primary health care at the turn of the millennium : evolution, changes and contrasts [PDF]

, 2000
Primary health care is a form of front-line medicine comparable to a valve with a filter. If either is blocked or weak, large amounts of relatively unimportant and trivial material will overflow, causing confusion and delays in the secondary channels ...
Xuereb, Joseph
core  

Primary health care in an academic medical center. [PDF]

, 1978
S B Thacker, Eva J. Salber, Charles E. Osborne, Lawrence H. Muhlbaier   +3 more
openalex   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Developing primary care services for stroke survivors: the Improving Primary Care After Stroke (IPCAS) research programme

Programme Grants for Applied Research
Background It is recognised that longer-term needs after stroke may not be well addressed by current services. The aim of this programme of research was to develop a novel primary care model to address these needs and to evaluate this new approach ...
Ricky Mullis, Maria Raisa Jessica Aquino, Elizabeth Kreit, Vicki Johnson, Julie Grant, Emily Blatchford, Mark Pilling, Francesco Fusco, Jonathan Mant   +8 more
doaj   +1 more source

The political economy of primary care and “health by the people”: An historical exploration [PDF]

, 1979
Oscar Gish
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Quality of primary health care in China: challenges and recommendations

The Lancet, 2020
Xi Li, H. Krumholz, W. Yip, K. Cheng, J. De Maeseneer, Q. Meng, Elias Mossialos, C. Li, Jiapeng Lu, Meng Su, Qiuli Zhang, D. Xu, Liming Li, S. Normand, R. Peto, Jing Li, Zengwu Wang, Hongbing Yan, R. Gao, S. Chunharas, Xin Gao, Raniero Guerra, Huijie Ji, Yang Ke, Zhigang Pan, Xian-ping Wu, S. Xiao, Xinying Xie, Yujuan Zhang, Jun Zhu, Shanzhu Zhu, Shengshou Hu   +31 more
semanticscholar   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

GEOGRAPHIC PROFILE OF HEALTHCARE NEEDS AND NON-ACUTE HEALTHCARE SUPPLY IN IRELAND. ESRI RESEARCH SERIES NUMBER 90 JULY 2019 [PDF]

, 2019
This report provides evidence on the supply of and need for non-acute primary, community and long-term care across geographic areas in Ireland in 2014.
Barron, Steve, Eighan, James, Lyons, Seán, Morgenroth, Edgar, Smith, Samantha, Walsh, Brendan, Wren, Maev-Ann   +6 more
core