Results 211 to 220 of about 2,092,566 (334)

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

The unique requirements of primary health care in Southern Africa

, 1986
D. P. Knobel
openalex   +2 more sources

Social Insurance Medicine: A Challenge to Primary Health Care [PDF]

, 1991
Gunnar Tellnes
openalex   +1 more source

Factors influencing access to primary health care in Luanda, Angola. [PDF]

BMC Health Serv Res
de Carvalho Maquengo AS, Bastos AM, Santana MS.   +2 more
europepmc   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

A project in re-inforcing the effectiveness of the primary care team in the area of mental health [PDF]

, 1991
Maria Rosen
openalex   +1 more source

Performance measurement systems in primary health care: a systematic literature review. [PDF]

BMC Health Serv Res
de Melo Santos CJ, Barbosa AS, Sant'Anna ÂMO.   +2 more
europepmc   +1 more source

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

FEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee, Gi‐Bang Koo, Jihye Park, Byung‐Cheol Han, Mijin Kwon, Seung‐Ho Lee   +5 more
wiley   +1 more source

Primary health care. [PDF]

Maghreb medical = al-Majallah al-tibbiyah lil-Maghrib al-'Arabi, 1982
openaire   +5 more sources

Primary Health Care: Public Involvement, Family Medicine Epidemiology, and Health Economics [PDF]

, 1992
Sonya R Murray
openalex   +1 more source