Results 21 to 30 of about 4,403,696 (255)

The organisation and delivery of health improvement in general practice and primary care: a scoping study [PDF]

, 2015
Background This project examines the organisation and delivery of health improvement activities by and within general practice and the primary health-care team. The project was designed to examine who delivers these interventions, where they are located,
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core   +3 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

A review of certain recent advances in primary health care [PDF]

, 2014
A strong primary health care system is the keystone of health care and helps patients manage their health conditions in the community, whilst also providing disease prevention services.
Baldacchino, Marilyn, Bezzina, Glorianne, Sammut, Mario R., Scerri, Anne Marie   +3 more
core  

Human resources for primary health care in sub-Saharan Africa: progress or stagnation? [PDF]

, 2015
BACKGROUND: The World Health Organization defines a "critical shortage" of health workers as being fewer than 2.28 health workers per 1000 population and failing to attain 80% coverage for deliveries by skilled birth attendants.
Bajunirwe, Francis, Daou, Pierre, De Maeseneer, Jan, Diakité, Chiaka, Diallo, Drissa, Hassan Mahmoud, Eman, Khogali, Mustafa, Mant, David, Moosa, Shabir, Mubangizi, Vincent, Nkomazana, Oathokwa, Peersman, Wim, Phaladze, Nthabiseng, Willcox, Merlin L   +13 more
core   +2 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Access and utilisation of primary health care services comparing urban and rural areas of Riyadh Providence, Kingdom of Saudi Arabia [PDF]

, 2017
The Kingdom of Saudi Arabia (KSA) has seen an increase in chronic diseases. International evidence suggests that early intervention is the best approach to reduce the burden of chronic disease. However, the limited research available suggests that health
A Almoajel, A Beckman, AD Lopez, AM Shabrawy el, AR Khan, AS Bakhashwain, B Cohen, B Shaikh, B Starfield, C Bcheraoui El, C Jenkinson, C Jenkinson, CA McHorney, CD James, D Griggs, D Yach, DH Peters, DH Peters, DN Ojanuga, DR Whiting, E Al-Faris, E Kontopantelis, E Scheppers, EI Al-Eissa, Erica J. Cook, G al-Qatari, GE Rosenthal, Ghadah Alfaqeeh, Gurch Randhawa, H Al-Shahrani, I Egharevba, IBM, J Frenk, J Macinko, JE Brazier, JE Shaw, JJ Hall, JP Kirscht, K Al-Sahili, K Walsh, L Ryan, M Al Yousuf, M Almalki, M Ramady, MC Beach, MES Ali, MM Al-Nozha, MS Alnaif, MZ al-Shahri, NA Qureshi, Nasreen Ali, NC Netzer, O Abodunrin, P Zhang, R Beaglehole, R Horne, R Kahn, RN Kuo, S Kar, S Yusuf, SM Ahmed, ST Syed, TA Arcury, United nations human settlements programme (UN-HABITAT), United nations human settlements programme (UN-HABITAT), World Health Organization, Z Hossain, ZM McLaren   +67 more
core   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Improving the health of people with multimorbidity: the need for prospective cohort studies [PDF]

, 2011
The dramatic rise in long-term conditions (LTCs) represents a major challenge for individuals, families, and health care systems worldwide. Due to the scale of this rise, the management of patients with LTCs largely falls within the domain of primary ...
Gunn, J., Mercer, S.W., Wyke, S.
core   +4 more sources

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source