Results 31 to 40 of about 2,047,237 (309)

Epidemiology of SARS-CoV2 in Qatar’s primary care population aged 10 years and above

BMC Infectious Diseases, 2021
Background There is an urgent need to elucidate the epidemiology of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and characterize its potential impact.
Mohamed Ahmed Syed, Ahmed Sameer Al Nuaimi, Hamda Abdulla A/Qotba, Gheyath K. Nasrallah, Asmaa A. Althani, Hadi M. Yassine, Abduljaleel Abdullatif Zainel, Hanan Khudadad, Tamara Marji, Shajitha Thekke Veettil, Hadeel T. Al-Jighefee, Salma Younes, Farah Shurrab, Duaa W. Al-Sadeq, Al Anoud Saleh AlFehaidi, Ameena Ibrahim Yfakhroo, Meshal Abdulla AlMesaifri, Hanan Al Mujalli, Samya Ahmad Al Abdulla, Mohamed Ghaith Al Kuwari, Faruk Mohammed Azad, Badria Ali Mohamed Al Malki, Mariam Ali Abdulmalik   +22 more
doaj   +1 more source

Knowledge, attitude, and proficiency of healthcare providers in cardiopulmonary resuscitation in a public primary healthcare setting in Qatar

Frontiers in Cardiovascular Medicine, 2023
IntroductionEarly and effective cardiopulmonary resuscitation (CPR) increases both survival rate and post–cardiac arrest quality of life. This study aims to assess the current knowledge and ability of physicians and nurses in health centers (HCs ...
Shajitha Thekke Veettil, Mohamed Shaheen Anodiyil, Hanan Khudadad, Mohamed Ali Kalathingal, Abdul Hakeem Hamza, Femina Purakaloth Ummer, Ahmed Sameer Alnuaimi   +6 more
doaj   +1 more source

Optimal primary care management of clinical osteoarthritis and joint pain in older people: a mixed-methods programme of systematic reviews, observational and qualitative studies, and randomised controlled trials

Programme Grants for Applied Research, 2018
Background: Osteoarthritis (OA) is the most common long-term condition managed in UK general practice. However, care is suboptimal despite evidence that primary care and community-based interventions can reduce OA pain and disability.
Elaine Hay, Krysia Dziedzic, Nadine Foster, George Peat, Danielle van der Windt, Bernadette Bartlam, Milisa Blagojevic-Bucknall, John Edwards, Emma Healey, Melanie Holden, Rhian Hughes, Clare Jinks, Kelvin Jordan, Sue Jowett, Martyn Lewis, Christian Mallen, Andrew Morden, Elaine Nicholls, Bie Nio Ong, Mark Porcheret, Jerome Wulff, Jesse Kigozi, Raymond Oppong, Zoe Paskins, Peter Croft   +24 more
doaj   +1 more source

Trends in the epidemiology of depression and comorbidities from 2000 to 2019 in Belgium

BMC Primary Care, 2022
Background Depression is a common mental disorder in family practice with an impact on global health. The aim of this study is to provide insight in the trends of epidemiological measures as well as pharmacological treatments and comorbidities of ...
Roosje Walrave, Simon Gabriël Beerten, Pavlos Mamouris, Kristien Coteur, Marc Van Nuland, Gijs Van Pottelbergh, Lidia Casas, Bert Vaes   +7 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Plantar heel pain in middle-aged and older adults: population prevalence, associations with health status and lifestyle factors, and frequency of healthcare use

BMC Musculoskeletal Disorders, 2019
Background The objectives of this study were to estimate the population prevalence and distribution of plantar heel pain in mid-to-older age groups, examine associations with selected health status and lifestyle factors, and report the frequency of ...
Martin J. Thomas, Rebecca Whittle, Hylton B. Menz, Trishna Rathod-Mistry, Michelle Marshall, Edward Roddy   +5 more
doaj   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source