Results 231 to 240 of about 6,771,945 (302)

Effects of Transcranial Pulse Stimulation of the Primary Motor Cortex on Motor Performance in Healthy Adults: A Randomized Crossover Pilot Study. [PDF]

CNS Neurosci Ther
Qin PP, Chak IK, Kan RL, Jin MX, Zhang BB, Xia AW, Lin TT, Wang SX, Liu JH, Cheung T, Kranz GS.   +10 more
europepmc   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Single-nucleus multiomic atlas of ALS primary motor cortex nominates neuroprotective WDR49-expressing astrocytes

Cooper-Knock J, Bonsall S, Kazu R, King M, Leung D, Mahiddine F, Highley J, Strange A, Chen Y, Sassani M, Eldahshoury M, Boyne J, Collins M, Monte E, Harvey C, Gornall S, Jangid A, Treanor C, Moll T, Dijk Cv, Cabras S, Urban A, Bowden K, Wareing H, Huang Y, Shaw P, West R, Kenna K, Hornstein E, Zhang S, Zhou J, Snyder M.   +31 more
europepmc   +1 more source

Slow-Oscillatory Transcranial Alternating Current Stimulation Over the Primary Motor Cortex Improves Motor Skill Acquisition. [PDF]

Eur J Neurosci
Miyaguchi S, Inukai Y, Igarashi K, Yamamoto S, Otsuru N, Onishi H.   +5 more
europepmc   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Endoplasmic reticulum stress within the primary motor cortex in hypobaric hypoxia-induced acute urinary retention. [PDF]

IBRO Neurosci Rep
Zhang Q, Ma Y, Lu C, Nie L, Chen H, Cao J, Zhao J, Huang Y.   +7 more
europepmc   +1 more source

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

Transcranial Direct Current Stimulation Targeting the Primary Motor Cortex Suppresses Activity in the Ventrolateral Periaqueductal Gray and Alleviates Chronic Pain in a Rat Model of Knee Osteoarthritis. [PDF]

J Pain Res
Xu Y, Fan C, Xue J, Gao C, Zhou Y, Li T.
europepmc   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

The laminar pattern of proprioceptive activation in human primary motor cortex. [PDF]

Cereb Cortex
Knudsen L, Guo F, Sharoh D, Huang J, Blicher JU, Lund TE, Zhou Y, Zhang P, Yang Y.   +8 more
europepmc   +1 more source