Results 291 to 300 of about 376,168 (350)

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source

Treadmill exercise prevents stress-induced anxiety-like behaviors via enhancing the excitatory input from the primary motor cortex to the thalamocortical circuit. [PDF]

Nat Commun
Luo Z, Chen J, Liu Y, Dai Y, Gao H, Zhang B, Ou H, So KF, Wei JA, Zhang L.   +9 more
europepmc   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Increase in beta frequency phase synchronization and power after a session of high frequency repetitive transcranial magnetic stimulation to the primary motor cortex. [PDF]

Neurotherapeutics
De Martino E, Casali AG, Nascimento Couto BA, Graven-Nielsen T, Ciampi de Andrade D.   +4 more
europepmc   +1 more source

A posture subspace in the primary motor cortex

Neuron
Patrick J. Marino, Lindsay Bahureksa, Carmen Fernández Fisac, Emily R. Oby, Adam L. Smoulder, Asma Motiwala, Alan D. Degenhart, Erinn M. Grigsby, Wilsaan M. Joiner, Steven M. Chase, Byron M. Yu, Aaron P. Batista   +11 more
openaire   +1 more source

Timing of high-definition transcranial direct current stimulation to the nondominant primary motor cortex fails to modulate cortical hemodynamic activity and improve motor sequence learning. [PDF]

J Neuroeng Rehabil
Jin M, Xu X, Zhang Z, Xia W, Lou X, Bai Z.   +5 more
europepmc   +1 more source

Intensity-Dependent Effects of Low-Frequency Subthreshold rTMS on Primary Motor Cortex Excitability and Interhemispheric Inhibition in Elderly Participants: A Randomized Trial. [PDF]

Neurorehabil Neural Repair
Wischnewski M, Edwards L, Revill KP, Drake D, Hobbs G, Buetefisch CM.   +5 more
europepmc   +1 more source

Giant pyramidal neurons of the primary motor cortex express vasoactive intestinal polypeptide (VIP), a known marker of cortical interneurons. [PDF]

Sci Rep
Teymornejad S, Worthy KH, Rosa MGP, Atapour N.   +3 more
europepmc   +1 more source

Bilateral Whisker Representations in the Primary Somatosensory Cortex in Robo3cKO Mice Are Reflected in the Primary Motor Cortex. [PDF]

Neuroscience
Tsytsarev V, Plachez C, Zhao S, O'Connor DH, Erzurumlu RS.   +4 more
europepmc   +1 more source