Results 121 to 130 of about 4,938,261 (300)

Understanding Cardiovascular Events With JAK Inhibitors: Similarities and Differences of the Vascular Effects Between Different JAK Inhibitors on Endothelial Cells Exposed to Inflammatory Cytokines

ACR Open Rheumatology, Volume 7, Issue 12, December 2025.
Objective A cardiovascular safety issue has been associated with JAK inhibitors (JAKi). This study compares the effects of distinct approved JAKi on endothelial cell (EC) dysfunction and apoptosis during inflammation. Methods Massive inflammation was induced in human vascular ECs by tumor necrosis factor (TNF) with interleukin‐17A (IL‐17A) treated or ...
Aliki Zavoriti, Pierre Miossec
wiley   +1 more source

SNPs array karyotyping reveals a novel recurrent 20p13 amplification in primary myelofibrosis. [PDF]

, 2011
The molecular pathogenesis of primary mielofibrosis (PMF) is still largely unknown. Recently, single-nucleotide polymorphism arrays (SNP-A) allowed for genome-wide profiling of copy-number alterations and acquired uniparental disomy (aUPD) at high ...
Alesiani, F., De Nictolis, M., Donati, M., Emiliani, R., Finelli, C., Gazzola, A., Isidori, A., Laginestra, M., Mannu, C., Paolini, S., Piccaluga, P., Pileri, S., Righi, S., Rossi, M., Sagramoso Sacchetti, C., Sapienza, M., Tripodo, C., Valentini, M., Visani, G.   +18 more
core   +1 more source

Supplementary Table 6 from FLT3-Mediated p38–MAPK Activation Participates in the Control of Megakaryopoiesis in Primary Myelofibrosis [PDF]

, 2023
Christophe Desterke, Chrystèle Bilhou‐Nabera, Bernadette Guerton, Christophe Martinaud, Carole Tonetti, Denis Clay, Paola Guglielmelli, Alessandro M. Vannucchi, Dominique Bordessoule, Hans Carl Hasselbalch, Brigitte Dupriez, Nassima Benzoubir, Marie‐Françoise Bourgeade, Olivier Pierre-Louis, Vladimir Lazar, William Vainchenker, Annelise Bennaceur‐Griscelli, Heinz Gisslinger, Stéphane Giraudier, Marie‐Caroline Le Bousse‐Kerdilès   +19 more
openalex   +1 more source

Predictors of Symptom Scores in Myeloproliferative Neoplasms: A Real‐World Retrospective Cohort Study

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Symptom management in myeloproliferative neoplasms (MPN) remains challenging despite advancements in disease‐directed therapies. This study assessed the impact of demographic, clinical, laboratory and treatment‐related variables on total symptom scores (TSS) and individual symptom scores in patients with polycythemia vera (PV ...
Muhammad Ali Khan, Syed Arsalan Ahmed Naqvi, John K. Camoriano, Cecilia Y. Arana Yi, Jennifer T. Andres, Joshua L. Blocher, Heidi E. Kosiorek, Irbaz Bin Riaz, Jeanne M. Palmer   +8 more
wiley   +1 more source

Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis [PDF]

, 2017
Primary Myelofibrosis (PMF) is a chronic Philadelphia-negative myeloproliferative neoplasm characterized by a skewed megakaryopoiesis and an overproduction of proinflammatory and profibrotic mediators that lead to the development of bone marrow (BM ...
Bianchi, Elisa, Guglielmelli, Paola, Manfredini, Rossella, Rontauroli, Sebastiano, Rossi, Chiara, Ruberti, Samantha, Salati, Simona, Tagliafico, Enrico, Vannucchi, Alessandro Maria, Zini, Roberta   +9 more
core   +2 more sources

Fibrocytes in primary myelofibrosis

Oncotarget, 2021
Shimoda, Kazuya, Ozono, Yoshinori, Shide, Kotaro   +2 more
openaire   +2 more sources

Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy

Haematologica, 2019
Myeloproliferative neoplasms (MPN), such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are characterized by the expansion of myeloid lineage cells caused by an acquired driver mutation, such as JAK2 V617F ...
Y. Fukuda, Marito Araki, Kouji Yamamoto, S. Morishita, Tadaaki Inano, K. Misawa, Tomonori Ochiai, Y. Edahiro, M. Imai, H. Yasuda, A. Gotoh, A. Ohsaka, N. Komatsu   +12 more
semanticscholar   +1 more source

Autoimmune Thrombocytopenia Treated by Low‐Dose Splenic Irradiation Followed by Splenectomy in a Patient With Systemic Lupus Erythematosus

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Severe autoimmune thrombocytopenia (ATP) in systemic lupus erythematosus (SLE) patients can be life‐threatening when refractory to standard treatments. Low‐dose splenic irradiation (LDSI) can provide temporary platelet recovery before definitive splenectomy.
Ryosuke Hanaoka
wiley   +1 more source

Childhood primary myelofibrosis presented with headache, splenomegaly, and severe thrombocytosis: A case report

Indian Journal of Medical and Paediatric Oncology, 2018
Primary myelofibrosis (PMF) is a clonal disorder of a multipotent hematopoietic progenitor cell that occurs predominantly in the elderly age group. We report here an 11-year-old girl who presented with headache, fever, and splenomegaly.
Athanasios Tragiannidis, Athanasia Apsemidou, Ioannis Liampas, Triantafyllia Koletsa   +3 more
doaj   +1 more source

Risk of other Cancers in Families with Melanoma : Novel Familial Links [PDF]

, 2017
A family history of cutaneous melanoma ('melanoma') is a well-established risk factor for melanoma. However, less is known about the possible familial associations of melanoma with other discordant cancers. A risk for discordant cancer may provide useful
Frank, Christoph, Hemminki, Akseli, Hemminki, Kari, Sundquist, Jan   +3 more
core   +1 more source