Results 121 to 130 of about 4,877,471 (249)

Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy

Haematologica, 2019
Myeloproliferative neoplasms (MPN), such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are characterized by the expansion of myeloid lineage cells caused by an acquired driver mutation, such as JAK2 V617F ...
Y. Fukuda, Marito Araki, Kouji Yamamoto, S. Morishita, Tadaaki Inano, K. Misawa, Tomonori Ochiai, Y. Edahiro, M. Imai, H. Yasuda, A. Gotoh, A. Ohsaka, N. Komatsu   +12 more
semanticscholar   +1 more source

Longitudinal In Vivo 3T MRI of Naturally Occurring Early Osteochondrosis Lesions in the Piglet Humeral Epiphyseal Cartilage and Growth Plate

Journal of Orthopaedic Research, Volume 43, Issue 11, Page 1934-1941, November 2025.
ABSTRACT Osteochondrosis/osteochondritis dissecans (OC/OCD) is a developmental orthopedic disease primarily affecting the knee, ankle, and elbow joints of children and multiple animal species. Subclinical lesions of OC/OCD have been described, but most can be visualized only histologically in cadaveric specimens.
Alexandra R. Armstrong, Erick O. Buko, Casey P. Johnson, Ferenc Tóth   +3 more
wiley   +1 more source

SNPs array karyotyping reveals a novel recurrent 20p13 amplification in primary myelofibrosis. [PDF]

, 2011
The molecular pathogenesis of primary mielofibrosis (PMF) is still largely unknown. Recently, single-nucleotide polymorphism arrays (SNP-A) allowed for genome-wide profiling of copy-number alterations and acquired uniparental disomy (aUPD) at high ...
Alesiani, F., De Nictolis, M., Donati, M., Emiliani, R., Finelli, C., Gazzola, A., Isidori, A., Laginestra, M., Mannu, C., Paolini, S., Piccaluga, P., Pileri, S., Righi, S., Rossi, M., Sagramoso Sacchetti, C., Sapienza, M., Tripodo, C., Valentini, M., Visani, G.   +18 more
core   +1 more source

Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis

Haematologica, 2013
Megakaryocytes release platelets into the bloodstream by elongating proplatelets. In this study, we showed that human megakaryocytes constitutively release Transforming Growth Factor β1 and express its receptors.
Stefania Badalucco, Christian Andrea Di Buduo, Rita Campanelli, Isabella Pallotta, Paolo Catarsi, Vittorio Rosti, David L. Kaplan, Giovanni Barosi, Margherita Massa, Alessandra Balduini   +9 more
doaj   +1 more source

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies [PDF]

, 2016
The Src family kinase (SFK)member SRC is amajor target in drug development because it is activated in many human cancers, yet deleterious SRC germline mutations have not been reported. We used genome sequencing and Human Phenotype Ontology patient coding
,, Ashford, Sofie, Attwood, Antony, Austin, Steve, Bakchoul, Tamam, Bariana, Tadbir K, Bradley, John R, Collins, Peter, De Maeyer, Marc, Deevi, Sri V V, Erber, Wendy N, Favier, Rémi, Freson, Kathleen, Gomez, Keith, Greene, Daniel, Kelly, Anne M, Kostadima, Myrto, Laffan, Michael A, Lambert, Michele P, Lentaigne, Claire, Lucy Raymond, F, Mathias, Mary, Millar, Carolyn M, Mumford, Andrew D, Nurden, Paquita, Ouwehand, Willem H, Papadia, Sofia, Peerlinck, Kathelijne, Penkett, Christopher J, Perry, David J, Rendon, Augusto, Richardson, Sylvia, Schulman, Sol, Selleslag, Dominik, Simeoni, Ilenia, Stephens, Jonathan C, Stirrups, Kathleen, Thys, Chantal, Turro, Ernest, Van Geet, Chris, Westbury, Sarah K, Whitehorn, Deborah, Wijgaerts, Anouck, Wittevrongel, Christine   +43 more
core   +1 more source

Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis

Journal of Experimental Medicine, 2016
Estrov and collaborators examine the role of fibrocytes in primary myelofibrosis and propose a novel therapeutic approach.
S. Verstovsek, T. Manshouri, D. Pilling, C. Bueso-Ramos, K. Newberry, Sanja Prijic, Ĺ. Knez, Ksenija Božinović, D. Harris, Erika L Spaeth, S. Post, A. Multani, R. Rampal, Jihae Ahn, R. Levine, C. Creighton, H. Kantarjian, Z. Estrov   +17 more
semanticscholar   +1 more source

Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms. [PDF]

, 2014
Myeloproliferative neoplasms (MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are predisposed to leukemic transformation.
de Haan, Gerald, Green, Anthony R, Kent, David G, Prick, Janine   +3 more
core   +1 more source

Validation of the WHO-defined 20% circulating blasts threshold for diagnosis of leukemic transformation in primary myelofibrosis

Blood Cancer Journal, 2018
Leukemic transformation is the most dreaded complication in patients with myeloproliferative neoplasms (MPN); overall risk is estimated at 14% for primary myelofibrosis (PMF), 7% for polycythemia vera (PV) and 4% for essential thrombocythemia (ET).
M. Mudireddy, N. Gangat, C. Hanson, R. Ketterling, A. Pardanani, A. Tefferi   +5 more
semanticscholar   +1 more source

What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog

Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson, King Long Hannah Lee, Megan Dietz, Sarah Guess, Laura White, Mara S. Varvil   +5 more
wiley   +1 more source

Ruxolitinib Treatment in a Patient with Primary Myelofibrosis Resistant to Conventional Therapies and Splenectomy: A Case Report

Turkish Journal of Hematology, 2015
A 67-year-old male patient who was diagnosed with primary myelofibrosis 4 years ago did not respond to conventional therapies. The splenomegaly progressively increased, which caused spleen infarctions and led to the decision to perform a splenectomy ...
Meltem Aylı, Muhit Özcan, Güldane Cengiz Seval   +2 more
doaj   +1 more source