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Treatment Algorithm for Primary and Secondary Myelofibrosis
, 2023 The management of primary myelofibrosis (PMF), postpolycythemia vera myelofibrosis (PPV-MF), and postessential thrombocythemia (PET-MF) is driven by their clinicopathologic and genomic characteristics, and their risk categories.
Harinder Gill
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Prognostication in Primary Myelofibrosis
Current Hematologic Malignancy Reports, 2011Primary myelofibrosis (PMF) is a Philadelphia chromosome-negative chronic myeloproliferative neoplasm usually affecting elderly people. Median survival currently approaches 6 years, with a few patients surviving more than 20 years but others dying soon after diagnosis. In 10% to 20% of patients, PMF evolves into acute leukemia.
Francisco, Cervantes, Arturo, Pereira
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Primary hypertrophic osteoarthropathy with myelofibrosis
Rheumatology International, 2007Primary hypertrophic osteoarthropathy or pachydermoperiostosis is a rare congenital disease characterized by clubbing of the fingers, periostitis of the distal long bones, and hypertrophic skin changes (pachydermia) including thick folds in the skin of the face, forehead, scalp and extremities, and also joint pain.
Massoud, Saghafi +2 more
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Renal complications of primary myelofibrosis
Leukemia & Lymphoma, 2018Primary myelofibrosis (PMF) is a disease of the elderly, with a median age at diagnosis of 71 years.
Paolo, Strati +7 more
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An unusual presentation of primary myelofibrosis
Indian Journal of Tuberculosis, 2018Extramedullary hematopoisis (EMH) normally occurs in fetal life, but it is pathological in later life and most of the time because of underlying marrow diseases. Sometimes EMH tissue can present with large masses which can cause compressive and constitutional symptoms. They can be wrongly diagnosed as malignancy and pulmonary tuberculosis. Here in this
Prateek, Tiwari +2 more
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OCULAR MANIFESTATIONS OF PRIMARY MYELOFIBROSIS
RETINAL Cases & Brief Reports, 2016Purpose: To report ocular manifestations of idiopathic primary myelofibrosis in a patient with relapsed primary myelofibrosis. Methods: Observational case report. Results: A 57-year-old African American male with history of primary ...
Albert L, Lin +4 more
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Ruxolitinib for the treatment of primary myelofibrosis
American Journal of Health-System Pharmacy, 2014The pharmacology, pharmacokinetics, pharmacogenomics, clinical efficacy, and safety profile of ruxolitinib for the treatment of primary myelofibrosis are reviewed.Ruxolitinib, an oral tyrosine kinase inhibitor that targets the Janus-associated kinases (JAKs) 1 and 2, has been recently approved for the treatment of patients with intermediate- or high ...
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Primary Myelofibrosis In Children
Blood, 2010Abstract Abstract 3079 Primary myelofibrosis is a chronic myeloproliferative disorder characterized by cytopenias, leukoerythroblastosis, extramedullary hematopoiesis, hepatosplenomegaly and bone marrow fibrosis. It is a serious medical condition in adults, often requiring major interventions such as hematopoietic stem ...
Melissa R. DeLario +7 more
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Distinguishing autoimmune myelofibrosis from primary myelofibrosis.
Clinical advances in hematology & oncology : H&O, 2018Bone marrow fibrosis (BMF) is a histologic finding in a wide range of diseases, including malignancies, endocrine disorders, autoimmune diseases, and infections. Autoimmune myelofibrosis (AIMF) is an uncommon etiology of BMF; it can be secondary to a defined autoimmune disease, or it can be primary in the absence of a clinically diagnosed autoimmune ...
Bridget, Marcellino +2 more
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