Results 11 to 20 of about 108,257 (197)

Recent advances in therapies for primary myelofibrosis. [PDF]

Fac Rev, 2023
Primary myelofibrosis (PMF), polycythemia vera (PV) and essential thrombocythemia (ET) form the classical BCR-ABL1-negative myeloproliferative neoplasms (MPNs) that are driven by a constitutive activation of JAK2 signaling. PMF as well as secondary MF (post-ET and post-PV MF) are the most aggressive MPNs.
Vainchenker W, Yahmi N, Havelange V, Marty C, Plo I, Constantinescu SN.   +5 more
europepmc   +4 more sources

Primary myelofibrosis L.

Онкогематология, 2014
Literature data of idiopathic myelofibrosis are presented: classification, diagnostic criteria, morphological and molecular features. Particular attention is given to therapy of various clinical forms of primary myelofibrosis.
L. M. Meshcheryakova, O. V. Porotkova, L. G. Kovaleva, L. Yu. Kolosova, S. N. Bychkova   +4 more
doaj   +5 more sources

Primary myelofibrosis: current therapeutic options

Revista Brasileira de Hematologia e Hemoterapia, 2016
Primary myelofibrosis is a Philadelphia-negative myeloproliferative neoplasm characterized by clonal myeloid expansion, followed by progressive fibrous connective tissue deposition in the bone marrow, resulting in bone marrow failure. Clonal evolution can also occur, with an increased risk of transformation to acute myeloid leukemia.
Paula de Melo Campos
openaire   +6 more sources

Is it primary myelofibrosis or chronic megakaryocytic leukemia? [PDF]

Haematologica, 2022
Lichtman MA.
europepmc   +4 more sources

Triple immunostaining demonstrates the possible existence of segregated-nucleus-containing atypical monocytes in human primary myelofibrosis bone marrow: a case report. [PDF]

J Med Case Rep
Background Segregated-nucleus-containing atypical monocytes have recently been identified in mice. Segregated-nucleus-containing atypical monocytes are thought to originate from the bone marrow and induce fibrosis in the drug-injured lung.
Homma S, Ogasawara T, Suga M, Nakamura Y, Takenaka K, Marshall S, Kawauchi K, Mori N, Kuroda H, Nakamura N, Miyagi Y, Masunaga A.   +11 more
europepmc   +2 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Disseminated tuberculosis with myelofibrosis presentation: a case report

Journal of Medical Case Reports, 2021
Background Primary myelofibrosis is a rare myeloproliferative disorder in middle-aged and old adults and should be distinguished from secondary and reactive causes of bone marrow fibrosis because, in reactive fibrosis, treatment approaches depend on the ...
Mahdi Khatuni, Marziyeh Ghalamkari, Fereshteh Ameli, Habibeh Yekehtaz   +3 more
doaj   +1 more source

Janus kinase 2 inhibition by pacritinib as potential therapeutic target for liver fibrosis

Hepatology, EarlyView., 2022
Diagram of the activation of the profibrotic and procontractile Janus kinase 2 (JAK2)/Ras homolog family member A/Rho‐kinase pathway and the inhibition of phosphorylated JAK2 by pacritinib to inhibit hepatic stellate cell activity. Abstract Background and Aims Janus kinase 2 (JAK2) signaling is increased in human and experimental liver fibrosis with ...
Sandra Torres, Cristina Ortiz, Nadine Bachtler, Wenyi Gu, Leon D. Grünewald, Nico Kraus, Robert Schierwagen, Christoph Hieber, Caroline Meier, Olaf Tyc, Maximilian Joseph Brol, Frank Erhard Uschner, Bart Nijmeijer, Christoph Welsch, Marie‐Luise Berres, Carmen Garcia‐Ruiz, Jose Carlos Fernandez‐Checa, Christian Trautwein, Thomas J. Vogl, Stefan Zeuzem, Jonel Trebicka, Sabine Klein   +21 more
wiley   +1 more source

Correlation between Primary Myelofibrosis and the Association of Portal Thrombosis with Portal-Biliary Cavernoma: US, MDCT, and MRI Features

Journal of Gastrointestinal and Abdominal Radiology, 2021
Objective Myelofibrosis is a rare chronic myelolymphoproliferative disease and is associated with increased risk of venous thromboembolism. The objective of this study is to retrospectively evaluate patients with primary myelofibrosis who underwent ...
Marco Di Girolamo, Stefania Galassi, Salvatore Merola, Paolo Bonome, Esmeralda Conte, Elsa Iannicelli   +5 more
doaj   +1 more source

Focus on Osteosclerotic Progression in Primary Myelofibrosis [PDF]

Biomolecules, 2021
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by hematopoietic stem-cell-derived clonal proliferation, leading to bone marrow (BM) fibrosis. Hematopoiesis alterations are closely associated with modifications of the BM microenvironment, characterized by defective interactions between vascular and endosteal niches.
Spampinato, Mariarita, Giallongo, Cesarina, Romano, Alessandra, Longhitano, Lucia, La Spina, Enrico, Avola, Roberto, Scandura, Grazia, Dulcamare, Ilaria, Bramanti, Vincenzo, Di Rosa, Michelino, Vicario, Nunzio, Parenti, Rosalba, Li Volti, Giovanni, Tibullo, Daniele, Palumbo, Giuseppe A   +14 more
openaire   +4 more sources